Abstract
These experiments were carried out to study, the effects of cold exposure on the permeability of blood-brain barrier (BBB) in hyperglycemic rats. The integrity of the BBB was investigated using Evans blue albumin (EBA) extravasation. Serum glucose levels in hyperglycemic rats were significantly higher than that obtained from normoglycemic rats (P < 0.05). Mean arterial blood pressure in hypothermic groups significantly dropped into lower levels, than that obtained in normothermic groups (P < 0.05). The EBA extravasation to the cerebellum in the group of cold exposure+acute hyperglycemia significantly increased compared with the values obtained from the cold exposure group (P < 0.05). The EBA extravasation to the brain regions of diabetic rats exposed to cold increased more than that in normotermic control rats (P < 0.05), but did not exceed the levels in cold controls. The result of this study suggests that, acute hyperglycemia superimposed upon the permeability of BBB in the rat exposed to cold, only in selected regions of the brain, especially the cerebellum, and this result could be an important factor to explain the mechanisms of death related with hyperglycemia+cold exposure in forensic medicine.
References
Nov 18, 1978·British Medical Journal·E A Gale, R B Tattersall
Jul 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·B OztaşS Camurcu
May 1, 1989·The Journal of Thoracic and Cardiovascular Surgery·W J GreeleyJ G Reves
Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·M MacariD L Eizirik
Jan 1, 1987·Stroke; a Journal of Cerebral Circulation·R B DuckrowR W Brennan
Aug 16, 1986·British Medical Journal·H A NeilJ E Baker
Jan 1, 1987·Acta Neuropathologica·J SchindelmeiserU Kersting
Dec 1, 1983·Anesthesiology·T IshikawaD G McDowall
Jan 1, 1983·Acta Neuropathologica·A Krantis
Dec 1, 1982·Cryobiology·W E HoffmanD J Miletich
Mar 1, 1994·Comparative Biochemistry and Physiology. Comparative Physiology·R D Kilgour, P A Williams
Dec 29, 1994·The New England Journal of Medicine·D F Danzl, R S Pozos
Nov 1, 1996·Journal of Neurosurgery·S MikawaP H Chan
Apr 1, 1997·Brain Research. Brain Research Reviews·A D Mooradian
May 20, 1998·Circulation·S B WilliamsM A Creager
Dec 9, 1998·Acta Neuropathologica·B LinR Busto
Feb 23, 1999·Clinical and Experimental Pharmacology & Physiology·N R SaundersK M Dziegielewska
Jul 6, 2000·British Journal of Pharmacology·A S De VrieseP M Vanhoutte
May 30, 2001·Forensic Science International : Synergy·I ElmasM Kaya
Feb 1, 1965·Annals of Surgery·D R MILLERA T STEEGMANN
Aug 11, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Tinoy J KizhakekuttuMichael E Widlansky
Citations
Nov 15, 2007·Infectious Agents and Cancer·Nikolai A Shevchuk, Sasa Radoja
Dec 22, 2010·Brain Research·Gui-Yun CuiYing-Dong Zhang
Jul 29, 2015·Forensic Science International : Synergy·C CattaneoD Gibelli
Dec 20, 2014·Molecular Medicine Reports·Dapeng GaoDawei Dai