Effects of acute cold stress on phagocytosis of apoptotic cells: the role of corticosterone

Neuroimmunomodulation
Renata Sesti-CostaBernardo Mantovani

Abstract

Stress can alter many aspects of the immune response, and many studies have been conducted on the effects of stress on inflammatory processes, but little is known about its influence on the resolution of inflammation in tissue homeostasis, which includes the clearance of apoptotic cells by macrophages in a non-phlogistic way. In the present study, we investigated the effect of acute cold stress on the phagocytosis of apoptotic cells by macrophages. Mice were submitted to acute cold stress (4 degrees C for 4 h) and the capacity of peritoneal macrophages to phagocyte apoptotic thymocytes and to secrete anti-inflammatory cytokines was evaluated. Plasma corticosterone and catecholamine levels were investigated to assess their effect on the phagocytic capacity of macrophages in vitro. We showed that acute cold stress decreases phagocytosis of apoptotic cells at the inflammatory site by lipopolysaccharide-activated macrophages but did not affect resting macrophages. The inhibitory effect on phagocytosis is accompanied by a reduced level of TGF-beta and higher IL-10 secretion. After stress, plasma concentrations of corticosterone increased 6-fold, epinephrine 2-fold and norepinephrine 1.7-fold compared to control mice. In vitro experi...Continue Reading

Citations

Jul 12, 2013·PloS One·Fangming XiuMarc G Jeschke
Jun 5, 2016·Comparative Immunology, Microbiology and Infectious Diseases·Stephanie HingStephanie S Godfrey
Jul 11, 2018·Frontiers in Immunology·Arnon Dias JurbergIngo Riederer
Jul 14, 2017·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·S V Gein, I L Sharav'eva
Jul 18, 2018·General and Comparative Endocrinology·Robert de Bruijn, L Michael Romero

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