Effects of acute hypoglycemia on working memory and language processing in adults with and without type 1 diabetes

Diabetes Care
Kate V AllenIan J Deary

Abstract

To examine the effects of hypoglycemia on language processing in adults with and without type 1 diabetes. Forty adults were studied (20 with type 1 diabetes and 20 healthy volunteers) using a hyperinsulinemic glucose clamp to lower blood glucose to 2.5 mmol/L (45 mg/dL) (hypoglycemia) for 60 min, or to maintain blood glucose at 4.5 mmol/L (81 mg/dL) (euglycemia), on separate occasions. Language tests were applied to assess the effects of hypoglycemia on the relationship between working memory and language (reading span), grammatical decoding (self-paced reading), and grammatical encoding (subject-verb agreement). Hypoglycemia caused a significant deterioration in reading span (P < 0.001; η(2) = 0.37; Cohen d = 0.65) and a fall in correct responses (P = 0.005; η(2) = 0.19; Cohen d = 0.41). On the self-paced reading test, the reading time for the first sentence fragment increased during hypoglycemia (P = 0.039; η(2) = 0.11; Cohen d = 0.25). For the reading of the next fragment, hypoglycemia affected the healthy volunteer group more than the adults with type 1 diabetes (P = 0.03; η(2) = 0.12; Cohen d = 0.25). However, hypoglycemia did not significantly affect the number of errors in sentence comprehension or the time taken to answ...Continue Reading

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Citations

Sep 13, 2015·Brain Research Bulletin·Seyed Fazel NabaviSeyed Mohammad Nabavi
Jan 7, 2017·The Quarterly Journal of Experimental Psychology : QJEP·André VandierendonckTimothy Desmet
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Feb 6, 2019·JAMA : the Journal of the American Medical Association·Niels SkipperJannet Svensson
Feb 8, 2019·Current Medicinal Chemistry·Jiyin ZhouGuisheng Qian
Apr 23, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Munachiso NwokoloPratik Choudhary
Feb 8, 2021·Diabetologia·Stephanie A Amiel

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