PMID: 8964945Mar 7, 1996Paper

Effects of acute hypoxia and hyperoxia on ventilation in spontaneously hypertensive and normotensive rat

Journal of the Autonomic Nervous System
O GriskA Honig

Abstract

The aim of this study was to investigate whether there are differences between particular characteristics of the ventilatory responses to acute hypoxia and hyperoxia in primary hypertensive and normotensive states which might indicate significant differences in arterial chemoreceptor reflex function. Pneumotachographic monitoring of ventilation was carried out in anesthetized, spontaneously breathing, normotensive randomly bred Wistar rats (NWR), Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). Under air breathing conditions, minute ventilation in SHR (50 +/- 2 ml/min per 100 g) was not significantly different from that of WKY (54 +/- 3 ml/min per 100 g) but NWR had a significantly lower minute ventilation (39 +/- 1 ml/min per 100 g) than both SHR and WKY. Our data indicate that there is no elevation of the ventilatory drive under air breathing conditions which can be unequivocally associated with primary hypertension in adult animals. During acute hypoxia, minute ventilation increased by a similar magnitude in SHR and NWR (by 97 and 77%, respectively, above baseline values), whereas in WKY the increase was only 58%. When exposed to acute hyperoxia, minute ventilation was inhibited by a similar degree in all a...Continue Reading

References

Jun 1, 1992·Hypertension·A Trzebski
Jan 1, 1991·The Japanese Journal of Physiology·H MatsumotoS Onodera
Jan 1, 1991·The Japanese Journal of Physiology·Y Fukuda
Mar 1, 1981·Circulation Research·N C Trippodo, E D Frohlich

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Citations

Feb 26, 2010·International Archives of Medicine·José R CisternasLuiz Carlos de Abreu
May 2, 2012·Autonomic Neuroscience : Basic & Clinical·Kouki KatoYoshio Yamamoto
Nov 4, 2011·Heart International·Vitor E ValentiCelso Ferreira
Jun 20, 2019·Equine Veterinary Journal·D BardellP J Cripps
Feb 6, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mariana Rosso MeloEduardo Colombari
Jun 17, 2016·The Journal of Trauma and Acute Care Surgery·Ashton Barnett-VanesSara M Rankin
May 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D B Jennings, H J Lockett

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