Effects of acute insulin-induced hypoglycaemia on psychomotor function: people with type 1 diabetes are less affected than non-diabetic adults.

Diabetologia
J GeddesB M Frier

Abstract

We examined the effects of acute insulin-induced hypoglycaemia on psychomotor function in non-diabetic volunteers and in adults with type 1 diabetes. Non-diabetic adults (n = 20) and adults with type 1 diabetes mellitus (n = 16) each underwent a euglycaemic-hyperinsulinaemic glucose clamp on two separate occasions. Arterialised blood glucose was maintained for 1 h at either 4.5 mmol/l (euglycaemia) or 2.5 mmol/l (hypoglycaemia). During this time participants underwent neuropsychological tests to assess psychomotor function. During hypoglycaemia the non-diabetic participants showed a significant deterioration in the following: (1) four-choice reaction time (p = 0.008); (2) grooved pegboard (a test of manual dexterity; p = 0.004); (3) hand steadiness (p = 0.003); (4) pursuit rotor (a test of fine motor function, attention and coordination; p = 0.018); and (5) test of total body coordination (p = 0.004). No significant differences were observed between euglycaemia and hypoglycaemia in hand-grip (p = 0.897) and line tracing time (p = 0.480) tests. In type 1 diabetes mellitus patients, only four-choice reaction time (p = 0.023) and pursuit rotor (p = 0.045) were impaired significantly during hypoglycaemia. Although acute hypoglycaem...Continue Reading

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Citations

Oct 21, 2011·Annals of Biomedical Engineering·Nuryani NuryaniH T Nguyen
Nov 18, 2011·Current Medical Research and Opinion·Andreas PfütznerT Forst
Feb 17, 2009·Diabetes/metabolism Research and Reviews
Jan 29, 2013·Diabetes, Obesity & Metabolism·B Inkster, B M Frier
Jul 8, 2015·Surgical Endoscopy·David Fenger Schefte, Steffen Jais Rosenstock
Feb 10, 2011·Journal of Diabetes Science and Technology·Julia PfütznerAndreas Pfützner

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