Effects of acute intermittent hypoxia on energy balance and hypothalamic feeding pathways

Neuroscience
Jason M Moreau, John Ciriello

Abstract

This study was done to investigate the effects of acute intermittent hypoxia (IH) on metabolic factors associated with energy balance and body weight, and on hypothalamic satiety-inducing pathways. Adult male Sprague-Dawley rats were exposed to either 8h IH or normoxic control conditions. Food intake, locomotion and body weights were examined after IH. Additionally, plasma levels of leptin, adiponectin corticosterone, insulin and blood glucose were measured following exposure to IH. Furthermore, adipose tissue was removed and analyzed for leptin and adiponectin content. Finally, the hypothalamic arcuate nucleus (ARC) was assessed for alterations in protein signaling associated with satiety. IH reduced body weight, food intake and active cycle locomotion without altering adipose tissue mass. Leptin protein content was reduced while adiponectin content was elevated in adipose tissue after IH. Plasma concentration of leptin was significantly increased while adiponectin decreased after IH. No changes were found in plasma corticosterone, insulin and blood glucose. In ARC, phosphorylation of signal transducer and activator of transcription-3 and pro-opiomelanocortin (POMC) expression were elevated. In addition, POMC-expressing neuron...Continue Reading

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Citations

Feb 10, 2016·Pflügers Archiv : European journal of physiology·Inês Alvarez-MartinsSérgio Dias
Jul 11, 2014·Journal of Insect Physiology·Manoush FarzinJon F Harrison
May 26, 2016·Neuroscience Letters·John CirielloDouglas L Jones
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