Abstract
Both acute kidney injury (AKI) and chronic kidney disease (CKD) are important issues in patients undergoing coronary artery bypass grafting (CABG), particularly with regard to mortality. However, their synergistic or discrete effects on long-term mortality remain unresolved. A total of 1,899 patients undergoing CABG were retrospectively analyzed. The adjusted hazard ratios for all-cause mortality were calculated after stratifying the timeframes. To evaluate the synergistic effects between AKI and CKD, the relative excess risk due to interaction was applied. The presence of AKI, CKD, or both increased the hazard ratios for mortality, compared with the absence of both: AKI alone, 1.84 (1.464-2.319); CKD alone, 2.46 (1.735-3.478); and AKI and CKD together, 3.21 (2.301-4.488). However, the relationships with mortality were different between AKI and CKD, according to the timeframes: AKI primarily affected early mortality, particularly within 3 years, whereas CKD had a relatively constant effect on both the early and late periods. When the parameters from the relative excess risk due to interaction were obtained, there was a synergistic additive effect on early mortality between AKI and CKD. The relationships with mortality after CAB...Continue Reading
References
Mar 13, 1999·Annals of Internal Medicine·A S LeveyD Roth
Sep 16, 2000·Intensive Care Medicine·A de MendonçaF Cantraine
Apr 6, 2004·The Annals of Thoracic Surgery·Johan NilssonJohan Brandt
May 27, 2005·The New England Journal of Medicine·Edward L HannanEric A Rose
Jan 20, 2006·European Heart Journal·Johan NilssonJohan Brandt
Feb 24, 2006·Circulation·William A CooperEric D Peterson
Feb 17, 2007·European Heart Journal·Martin J HolzmannTorbjörn Ivert
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Mitchell H Rosner, Mark D Okusa
Aug 15, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Sawako KatoBengt Lindholm
Nov 21, 2008·Journal of the American Society of Nephrology : JASN·Areef IshaniAllan J Collins
Feb 13, 2009·American Journal of Epidemiology·David B Richardson, Jay S Kaufman
Apr 29, 2009·Circulation·Charles E HobsonAzra Bihorac
Sep 17, 2009·JAMA : the Journal of the American Medical Association·Ron WaldUNKNOWN University of Toronto Acute Kidney Injury Research Group
Nov 10, 2010·Journal of Korean Medical Science·Chung Sik LeeYon Su Kim
Nov 26, 2010·Lancet·Matthew T JamesUNKNOWN Alberta Kidney Disease Network
Sep 17, 2011·American Journal of Physiology. Renal Physiology·Richard A ZagerKirsten Becker
Feb 15, 2012·Archives of Internal Medicine·Amit P AminMikhail Kosiborod
May 1, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jason JonesMichel Chonchol
Sep 27, 2012·Current Opinion in Nephrology and Hypertension·Michael Heung, Lakhmir S Chawla
Aug 31, 2013·Kidney International·Konrad M Andrassy
Jan 18, 2014·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Mona Al RukhaimiFaissal A M Shaheen
Mar 7, 2014·Journal of the American Heart Association·Martin HolzmannUlrik Sartipy
Citations
Nov 6, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Suguru OhiraHitoshi Yaku
Dec 29, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Eeva-Maija KinnunenFausto Biancari
Aug 18, 2016·International Journal of Cardiology·Shao-Wei ChenTien-Hsing Chen
Jan 17, 2019·Interactive Cardiovascular and Thoracic Surgery·Zhiwei LiKegang Jia
May 14, 2019·Nephrology·Ji Eun KimSeung Seok Han
May 28, 2019·Medicine·Yeonhee LeeSeung Seok Han
May 13, 2020·Journal of Cardiothoracic Surgery·Zhiyuan GuanChunli Song
Jan 20, 2016·MMW Fortschritte der Medizin·H Holzgreve
Jan 27, 2019·Critical Care : the Official Journal of the Critical Care Forum·Gijs FortrieMichiel G H Betjes
Nov 8, 2016·Current Opinion in Anaesthesiology·Dana Y Fuhrman, John A Kellum
Nov 3, 2020·The Annals of Thoracic Surgery·Daniel T EngelmanThomas A Schwann
Jun 6, 2021·Seminars in Thoracic and Cardiovascular Surgery·Soichiro HenmiKenji Okada
Aug 21, 2021·Journal of Cardiac Surgery·Cesar E Mendoza, Gustavo A Vargas