PMID: 6965708Jan 1, 1980Paper

Effects of acute lithium administration on conditioned avoidance behavior and monoamine synthesis in rats

Journal of Neural Transmission
U BerggrenJ Engel

Abstract

The effect of a single injection of various doses of lithium chloride was tested on conditioned avoidance behavior and on the accumulation of DOPA and 5-HTP after inhibition of aromatic amino acid decarboxylase. Lithium specifically suppressed conditioned avoidance behavior and reduced formation of DOPA, but not 5-HTP. The behavioral effect of lithium could be completely antagonized with additional L-DOPA treatment. The results indicate that lithium has a neuroleptlike effect on avoidance behavior, and it is suggested that some of the behavioral effects of lithium may be mediated via interference with central catecholaminergic mechanisms.

References

Sep 15, 1978·Psychopharmacology·U BerggrenJ Engel
Apr 23, 1974·Psychopharmacologia·C DaviesD C U'Prichard
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·P BédardM Lindqvist
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·W KehrM Lindqvist
Jul 1, 1971·Journal of Neurochemistry·A TagliamonteG L Gessa
Jun 1, 1968·Journal of Psychiatric Research·M Schou
Jan 1, 1967·Acta Physiologica Scandinavica·N E Andén, T Magnusson
Jul 30, 1971·Nature·C CoxM Tomkiewicz
Mar 1, 1970·Life Sciences·M H Sheard, G K Aghajanian

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