PMID: 3745781Aug 1, 1986Paper

Effects of acute myocardial infarction on the circulation of the conscious rat

Journal of the Autonomic Nervous System
P H RatzS F Flaim

Abstract

This study was conducted to determine if experimental left coronary artery ligation resulting in a small myocardial infarction (MI, 15% of the left ventricle) affects the peripheral circulation in conscious rat during the first 48 h of recovery. At 24 or 48 h post-MI or sham surgery, animals were instrumented and evaluated using the radioactive microsphere technique. There were no overt central hemodynamic changes 24 h post-MI but at 48 h, left ventricular end diastolic pressure was significantly increased compared to the parallel control (MI: 5.9 +/- 0.6, sham 2.0 +/- 0.5 mm Hg, P less than 0.005). At 24 h post-MI, renal vascular resistance was increased and similar but non-significant changes occurred in the gut. At 48 h post-MI, vascular resistance in the skeletal muscle, spleen, gut and cutaneous circulations were significantly reduced compared to sham-operated rats. Similar changes at 24 h were seen in a separate group of conscious rats with MI which had previously undergone cardiac denervation suggesting that cardiac afferent activity was not directly responsible for the peripheral response to MI at 24 h. Denervation did eliminate the 48 h peripheral vasodilator response. In denervated animals, circulating renin levels we...Continue Reading

References

Mar 1, 1979·Acta Physiologica Scandinavica·P ThorénS E Ricksten
Mar 1, 1978·The Journal of Clinical Investigation·D MacleanP R Maroko
Jul 1, 1977·Progress in Cardiovascular Diseases·M A HeymannA M Rudolph
May 1, 1973·Acta Physiologica Scandinavica·B Oberg, P Thorén
Nov 1, 1969·Investigative Radiology·H N WagnerJ P Ryan
Mar 1, 1984·Journal of Pharmacological Methods·S F FlaimE D Newman
Dec 1, 1964·Circulation Research·E M KRIEGER

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Citations

Jun 1, 1987·Journal of the Autonomic Nervous System·A K PeresR Zelis
Sep 1, 1988·Journal of Pharmacological Methods·O S MedvedevV Y Khalatov

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