Effects of acute stimulation with gonadotropin releasing hormone (GnRH) on biologically active serum luteinizing hormone (LH) in elderly men

Journal of Endocrinological Investigation
M F CelaniP Marrama

Abstract

This study was designed to characterize the response pattern of biologically active LH (BIO-LH) after Gonadotropin Releasing Hormone (GnRH) acute administration in healthy elderly men, in comparison with normal young adult men. Serum levels of BIO-LH under basal conditions and in response to the iv injection of 0.1 mg synthetic GnRH were measured in 6 healthy elderly men (mean age 74.2 yr), as well as in 9 normal young men (mean age 27.4 yr). A sensitive in vitro bioassay, based upon testosterone production by mechanically dispersed mouse Leydig cells, was employed to assess LH biological activity. Levels of immunoreactive LH (RIA-LH) and basal testosterone (T) concentrations were determined by a double antibody radioimmunoassay technique. Mean basal levels of BIO-LH and RIA-LH were significantly increased in elderly men, compared to levels in young men, whereas the mean basal ratio of LH in vitro bioactivity to LH immunoreactivity (LH B/I ratio) and mean basal T concentrations were significantly lower in the elderly group. After GnRH administration, the B/I ratio of serum LH remained unchanged both in elderly and in young men. The mean relative maximum response for BIO-LH (BIO-LH delta %) was significantly lower in elderly men...Continue Reading

References

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Citations

Jan 1, 1988·Archives of Andrology·B A Keel
Jan 31, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Alvin M Matsumoto
Oct 6, 2011·American Journal of Physiology. Endocrinology and Metabolism·Johannes D VeldhuisPaul Y Takahashi
Dec 13, 2000·Experimental Gerontology·J D Veldhuis

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