Effects of acute stress on cardiac endocannabinoids, lipogenesis, and inflammation in rats

Psychosomatic Medicine
Ellen Alison HolmanDaniele Piomelli

Abstract

Trauma exposure can precipitate acute stress (AS) and cardiovascular disorders (CVD). Identifying AS-related physiologic changes that affect CVD risk could inform development of early CVD prevention strategies. The endocannabinoid system (ECS) regulates hypothalamic-pituitary-adrenal axis and stress-related cardiovascular function. We examine stress-related ECS activity and its association with cardiovascular biochemistry/function after AS. Rodents (n = 8-16/group) were exposed to predator odor or saline; elevated plus maze, blood pressure, serum and cardiac ECS markers, and lipid metabolism were assessed 24 hours and 2 weeks postexposure. At 24 hours, the predator odor group demonstrated anxiety-like behavior and had a) elevated serum markers of cardiac failure/damage (brain natriuretic peptide: 275.1 versus 234.6, p = .007; troponin I: 1.50 versus 0.78, p = .076), lipogenesis (triacylglycerols: 123.5 versus 85.93, p = .018), and inflammation (stearoyl delta-9 desaturase activity: 0.21 versus 0.07, p < .001); b) decreased cardiac 2-arachidonoyl-sn-glycerol (29.90 versus 65.95, p < .001), oleoylethanolamide (114.3 versus 125.4, p = .047), and palmitoylethanolamide (72.96 versus 82.87, p = .008); and c) increased cardiac inflamm...Continue Reading

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Citations

Mar 1, 2016·Psychoneuroendocrinology·Sarah WilkerIris-Tatjana Kolassa
Sep 12, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James LimDaniele Piomelli
Apr 8, 2015·Journal of Molecular Psychiatry·Alexander KarabatsiakisIris-Tatjana Kolassa
Nov 6, 2018·Expert Review of Proteomics·Dario Aspesi, Graziano Pinna
Feb 12, 2019·Behavioural Pharmacology·Dario Aspesi, Graziano Pinna
May 7, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Devon IvyDaniele Piomelli
Aug 23, 2018·Frontiers in Neuroscience·Graziano Pinna
Mar 4, 2021·Reviews in the Neurosciences·Tomasz BielawskiDorota Frydecka
Aug 12, 2018·Journal of Psychosomatic Research·Dana Rose GarfinE Alison Holman
Dec 27, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·Andrea Locci, Graziano Pinna
Jun 8, 2021·Frontiers in Psychiatry·Graziano Pinna

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