Effects of Acute Stroke Serum on Non-Ischemic Cerebral and Mesenteric Vascular Function

Translational Stroke Research
Isabella CanaveroM J Cipolla

Abstract

We investigated the effects of circulating factors in serum obtained from patients in the acute phase of different subtypes of ischemic stroke on non-ischemic cerebral and mesenteric arteries, as a potential mechanism involved in influencing regional perfusion and thus clinical evolution. Posterior cerebral arteries (PCAs) and mesentery arteries (MAs) isolated from Wistar Kyoto rats were perfused with serum from acute stroke patients with large vessel disease without (LVD) or with hypertension (LVD + HTN), cardioembolism with hypertension (CE + HTN), or physiologic saline as controls. Myogenic activity and nitric oxide-dependent vasorelaxation were assessed after 2 h of intraluminal exposure to serum. Vascular function was differentially affected by sera. Exposure to LVD serum increased myogenic tone and produced endothelial dysfunction in both PCAs and MAs. However, CE + HTN serum increased tone and decreased smooth muscle sensitivity to NO in vessels from both vascular beds. LVD + HTN serum was associated with reduced smooth muscle sensitivity to NO in vessels from both vascular beds but increased tone only in PCAs. Inflammation and oxidative stress, determined by measurement of high sensitivity C-reactive protein, uric acid,...Continue Reading

References

Aug 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A M HakimE Meyer
Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·T BrottV Hertzberg
May 1, 1988·Stroke; a Journal of Cerebral Circulation·J C van SwietenJ van Gijn
Apr 1, 1997·Stroke; a Journal of Cerebral Circulation·S W HoffmanE F Ellis
Jul 11, 1998·Stroke; a Journal of Cerebral Circulation·M SilvestriniG Bernardi
Jul 11, 2001·Journal of Cardiovascular Pharmacology·J KählerT Münzel
Oct 27, 2001·Circulation Research·G J Blake, P M Ridker
May 4, 2002·Stroke; a Journal of Cerebral Circulation·Jo Leonardi-BeeUNKNOWN IST Collaborative Group
Feb 12, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Elisabet Vila, Mercedes Salaices
Feb 19, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Erion QamiraniTravis W Hein
Apr 28, 2005·Expert Review of Neurotherapeutics·David S Liebeskind
Nov 5, 2005·Stroke; a Journal of Cerebral Circulation·Jean-Martin VincentJean-Marc Chillon
Mar 18, 2006·Acta Neurologica Scandinavica·J Pretnar-OblakM Zaletel
Jul 1, 2006·Stroke; a Journal of Cerebral Circulation·Claes LadenvallPer Ladenvall
Jun 22, 2007·Journal of the Neurological Sciences·Robert J Wityk
Oct 2, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·John W EikelboomQilong Yi
Nov 13, 2007·Free Radical Biology & Medicine·Mario ComportiConcetta Gardi
Jun 7, 2008·Stroke; a Journal of Cerebral Circulation·Joan MontanerJosé Alvarez-Sabín
Oct 22, 2008·Trends in Molecular Medicine·Sophocles Chrissobolis, Frank M Faraci
May 6, 2009·Biochemical Pharmacology·Alexander H Sprague, Raouf A Khalil
Sep 18, 2009·Atherosclerosis·Raymond C S SeetChristopher P Chen
Feb 27, 2010·Stroke; a Journal of Cerebral Circulation·Carmen DomínguezJoan Montaner
Oct 12, 2010·Stroke; a Journal of Cerebral Circulation·Marcel J H AriesPatrick C A J Vroomen
Feb 8, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fernando Rodríguez-PascualSantiago Lamas
Jun 28, 2011·Stroke; a Journal of Cerebral Circulation·Raymond C S SeetBarry Halliwell
Mar 1, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sara Morales PalomaresMarilyn J Cipolla

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Citations

Jul 25, 2017·Experimental Physiology·Shinichi AsanoPaul D Chantler
Apr 11, 2017·Redox Report : Communications in Free Radical Research·Alexander Vladimirovich IvanovAslan Amirkhanovich Kubatiev
Jul 1, 2019·Clinical Neurology and Neurosurgery·Marina Yurievna MaksimovaAslan Amirkhanovich Kubatiev

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