PMID: 7545268Jun 1, 1995Paper

Effects of acute systemic treatment with the 5 HT-uptake blocker alaproclate on tissue levels and release of substance P in rat periaqueductal grey

Neuropeptides
A RosénE Brodin

Abstract

The effects of acute systemic treatment with alaproclate, a serotonin uptake blocker on regional brain tissue levels of substance P, neurokinin A and cholecystokinin were studied in the rat. The peptide levels of all three peptides were increased (23-35%) in the rat periaqueductal grey 60 min after treatment with alaproclate (20 mumol/kg peroral, p.o.), compared to controls. In the cingulate cortex, the tissue levels of substance P and cholecystokinin were increased (19-32%) after subcutaneous (s.c.) treatment with alaproclate, compared to controls. Higher tissue levels of all three peptides (20-38%) in the periaqueductal grey, and lower levels of substance P and cholecystokinin in the cingulate cortex were found following saline s.c. compared to saline p.o., probably due to different degrees of stress. In microdialysis experiments, a s.c. injection of either saline (2 ml/kg), alaproclate (20 mumol/kg) or morphine (3 mg/kg) was found to slowly increase the substance P release in the periaqueductal grey. Experiments with the selective 5-HT neurotoxin, 5,7-dihydroxytryptamine indicated no neuronal co-existence of substance P and serotonin in the periaqueductal grey and cingulate cortex. In conclusion, acute treatment with the ser...Continue Reading

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Citations

Jul 6, 2006·Amino Acids·K Ebner, N Singewald
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·S C StoutC B Nemeroff
Sep 4, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Innar TõruJakov Shlik
May 2, 2002·The Australian and New Zealand Journal of Psychiatry·Graham MeadowsIrene Bobevski
May 19, 2000·Annals of the New York Academy of Sciences·L LundebergO Johansson
Aug 7, 2021·Autonomic Neuroscience : Basic & Clinical·Hyun Jin Jung, Ronny Priefer

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