Effects of acute treatment with antidepressant drugs on sensorimotor gating deficits in rats

Psychopharmacology
B PouzetS Hogg

Abstract

Schizophrenic patients have a deficit in prepulse inhibition (PPI) which can be modelled in rats by administration of direct or indirect dopamine (DA) receptor agonists and N-methyl-D-aspartate (NMDA) receptor antagonists. Moreover, antipsychotics reverse the disruptive effect of DA agonists and NMDA receptor antagonists in this rat model. Consequently, this model is considered as predictive of antipsychotic action in the clinic. However, the effect of compounds, such as antidepressants, used for other psychiatric disorders but also administered to patients with schizophrenia has not been well investigated in this model. Antidepressants have been suggested not to affect PPI in humans. Thus, antidepressants are not expected to antagonise PPI disruption in rats, and should normally be used as negative controls in this model. To investigate the effects of three antidepressant compounds, a serotonin reuptake inhibitor, a dopamine reuptake inhibitor, and a noradrenaline reuptake inhibitor in the rat PPI model. The effect of acute treatment with citalopram, bupropion and desipramine on d-amphetamine-disrupted and phencyclidine (PCP)-disrupted PPI in rats was investigated. Ziprasidone was tested as a positive control. None of the anti...Continue Reading

References

Mar 1, 1992·Archives of General Psychiatry·D L BraffM A Geyer
Feb 1, 1990·Archives of General Psychiatry·D L Braff, M A Geyer
Oct 1, 1989·Archives of General Psychiatry·M S KramerI Kimes
Dec 1, 1989·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·R S Mansbach, M A Geyer
Jan 1, 1987·Progress in Neuro-psychopharmacology & Biological Psychiatry·L SteruR D Porsolt
Jan 1, 1988·Psychopharmacology·R S MansbachD L Braff
Jun 1, 1996·Journal of Clinical Psychopharmacology·E Richelson
Mar 24, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·G B VartyM A Geyer
Jun 15, 1999·Psychopharmacology·K E Hutchison, R Swift
Aug 5, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·H Y Meltzer
May 11, 2000·Psychopharmacology·J ZhangL Svensson
May 24, 2000·Psychopharmacology·S C DulawaM A Geyer
May 5, 2001·Expert Opinion on Pharmacotherapy·B G Pollock
Aug 18, 2001·Pharmacology, Biochemistry, and Behavior·R S MansbachS H Zorn
Oct 19, 2001·CNS Drug Reviews·H Silver
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·B PouzetJ Arnt
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·B PouzetJ Arnt

❮ Previous
Next ❯

Citations

Apr 22, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karen M Alsene, Vaishali P Bakshi
Dec 14, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James M DohertyMark A Geyer
Nov 18, 2008·Biological Psychiatry·Nancy A ShanahanStephanie C Dulawa
May 8, 2007·Neuron·Steven J ClapcoteJohn C Roder
Jan 13, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Motoyasu YamashitaIchiro Sora
Sep 29, 2007·European Archives of Psychiatry and Clinical Neuroscience·Christine NorraHanns Jürgen Kunert
Dec 17, 2009·Psychopharmacology·Tatiana Lipina, John Roder
Nov 5, 2019·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hwayoung LeeHak-Jae Kim
Apr 19, 2020·Hormones and Behavior·Raquell de Castro ChavesFrancisca Cléa Florenço de Sousa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here