PMID: 8595618Nov 1, 1995Paper

Effects of acutely raising intracranial pressure on cardiac sympathetic efferent neuron function

Cardiovascular Research
D A MurphyJohn Andrew Armour

Abstract

To determine whether acutely raising intracranial pressure modifies the function of cardiac efferent autonomic neurons. The effects of suddenly raising intracranial pressure above systemic vascular pressure on heart rate, left atrial and left ventricular chamber pressures, as well as right and left ventricular intramyocardial pressures, were studied following removal of the adrenal glands from the circulation. Cardiac effects induced by systemic administration of nicotine, tyramine or isoproterenol were investigated before and after raising intracranial pressure: (1) in 9 dogs with neurally intact hearts in which cardiac release of catecholamines and intrinsic cardiac neuronal activity were studied; (2) in another 8 dogs in which intrathoracic autonomic neurons were disconnected from central neurons; (3) in another 8 dogs after decentralizing intrathoracic sympathetic but not parasympathetic neurons; (4) in 2 animals after decentralizing intrathoracic parasympathetic, not sympathetic neurons. Increasing intracranial pressure in neurally intact preparations induced ventricular augmentation followed by depression such that after 12 min of cerebral ischemia left ventricular systolic pressure was 62 +/- 5 mmHg. Isoproterenol and ty...Continue Reading

Citations

Oct 8, 2009·Circulation. Arrhythmia and Electrophysiology·Suraj Kapa, Samuel J Asirvatham

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