Effects of adenosine A(3) receptor agonist on bone marrow granulocytic system in 5-fluorouracil-treated mice

European Journal of Pharmacology
Michal HoferDenisa Streitová

Abstract

The purpose of the experiments reported was to investigate effects of N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA), a selective adenosine A(3) receptor agonist, on the granulocytic system in femoral marrow of mice depleted by the cytotoxic drug 5-fluorouracil. In the phase of the highest cell depletion IB-MECA was injected i.p. at single doses of 200 nmol/kg given either once or twice daily in 2- and 4-day regimens starting on day 1 after 5-fluorouracil administration; the effects were evaluated on days 3 and 5, respectively. The general effect of IB-MECA in all these experiments was an enhancement of the counts of morphologically recognizable proliferative granulocytic cells, interpreted as evidence of the differentiation of committed progenitor cells. A more expressive effect was observed after IB-MECA injected twice daily. It was found that the induction of the strong differentiation pressures by IB-MECA given twice daily shortly after 5-fluorouracil treatment can be counterproductive due to the preponderance of differentiaton processes over the proliferation control. In additional experiments, it has been shown that the use of the 2-day administration of IB-MECA given twice daily in the recovery phase, i.e., ...Continue Reading

References

Aug 16, 2001·Critical Reviews in Toxicology·E J Calabrese
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Jan 22, 2005·European Journal of Pharmacology·Milan PospísilVladimír Znojil

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Citations

Mar 2, 2012·Molecular Biology of the Cell·Frauke GoemanGiulia Piaggio
Sep 21, 2007·Cancer Investigation·Denisa StreitováVladimír Znojil
Jul 2, 2011·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Michal HoferLenka Weiterová
Mar 27, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Michal HoferDenisa Streitová
May 1, 2008·Experimental Biology and Medicine·Michal HoferAntonín Vacek
Jan 19, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michal HoferZuzana Hoferova
Jul 25, 2019·Current Pharmaceutical Design·Bapi GorainSubrat Kumar Bhattamisra
Jul 20, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rosalyn WagnerJörg Reutershan
Jun 14, 2019·Expert Opinion on Therapeutic Targets·Stefania MerighiStefania Gessi
Oct 16, 2014·Physiological Research·M HoferD Komůrková

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