PMID: 3760388Nov 1, 1986Paper

Effects of adenosine and adenosine 5'-triphosphate on ventricular escape rhythm in the canine heart

Journal of the American College of Cardiology
A PellegL S Dreifus

Abstract

The effects of adenosine and adenosine 5'-triphosphate (ATP) on ventricular escape rhythms were studied in 16 closed chest dogs after electroablation of the His bundle region. All dogs exhibited complete atrioventricular (AV) block and stable ventricular escape rhythm with a mean cycle length of 1,210 +/- 80 ms and a QRS width of 91 +/- 5 ms. Physiologic AV sequential pacing was operative during experiments and was interrupted for rapid (less than or equal to 1 second) administration of either adenosine or ATP (3 mumol/kg) into the right atrium. Adenosine and ATP effectively depressed ventricular escape rhythms in a similar manner both qualitatively and quantitatively (cycle length from 1,210 +/- 80 to 1,764 +/- 132 ms and from 1,274 +/- 84 to 2,000 +/- 150 ms, respectively; each p less than 0.01). These effects were not significantly altered by either physostigmine (an acetylcholinesterase inhibitor) or atropine (a muscarinic cholinergic blocker), but were slightly attenuated by propranolol (a beta-adrenoceptor blocker). In the presence of autonomic blockade, the adenosine transport blocker dipyridamole markedly enhanced the depressant effects of adenosine and ATP. The adenosine competitive antagonist aminophylline reversed th...Continue Reading

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Citations

Jul 1, 1997·Trends in Pharmacological Sciences·A Pelleg, S P Kutalek
Aug 1, 1987·Journal of the American College of Cardiology·L Constantin, J B Martins
Mar 19, 2002·American Journal of Therapeutics·Amir PellegSteven P Kutalek
Dec 1, 1988·The Journal of Clinical Investigation·B B LermanL Belardinelli
Jul 1, 1992·The American Journal of Emergency Medicine·S L Orebaugh, M Handy
May 1, 1991·Circulation·B B Lerman, L Belardinelli
Jan 1, 1990·Annals of the New York Academy of Sciences·A PellegE L Michelson
Feb 24, 2015·American Journal of Therapeutics·Daniel FlammangAmir Pelleg
Jul 1, 1989·Progress in Cardiovascular Diseases·L BelardinelliR M Berne

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