Effects of adenosine and ATP on the membrane potential and synaptic transmission in neurons of the rat locus coeruleus

The Kurume Medical Journal
Takashi Kuwahata

Abstract

Effects of adenosine (Ado) and adenosine 5'-triphosphate (ATP) on the membrane potential and synaptic transmission in neurons of the rat locus coeruleus (LC) were examined, in vitro. Ado (30-300 microM) produced a hyperpolarizing response and inhibited spontaneous firing activity in neurons of the rat LC. Ado decreased input resistance of LC neurons. The Ado-induced hyperpolarization reversed polarity near the equilibrium potential of K+ (EK). Ado (100-300 microM) depressed both excitatory postsynaptic potential (EPSP) and inhibitory postsynaptic potential (IPSP). Ado (300 microM) did not alter the hyperpolarization induced by norepinephrine (30 microM). N6-Cyclopentyladenosine (CPA, 100 microM), an A1 receptor agonist, also produced a hyperpolarizing response and depressed both the EPSP and IPSP. Another A1 receptor agonist, adenosine amine congener (ADAC, 30 microM) also produced a hyperpolarizing response and consistently depressed the EPSP and IPSP. Application of ATP (100 microM) to LC neurons caused a depolarizing response associated with an increase in the firing rate of spontaneous action potential in LC neurons. The ATP-induced depolarization was accompanied by an increased input resistance and reversed polarity at--91...Continue Reading

Citations

Feb 24, 2012·Journal of Neurophysiology·J M HawrylukE Arrigoni
Mar 1, 2005·British Journal of Pharmacology·Song T Yao, Andrew J Lawrence
Sep 4, 2014·Frontiers in Physiology·Débora de CarvalhoLuciane H Gargaglioni
Feb 16, 2021·Frontiers in Physiology·Joe Rowland Adams, Aneta Stefanovska

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