Effects of adenosine on myocardial glucose and palmitate metabolism after transient ischemia: role of 5'-AMP-activated protein kinase

American Journal of Physiology. Heart and Circulatory Physiology
Jagdip S JaswalAlexander S Clanachan

Abstract

Loss of cardioprotection by adenosine in hearts stressed by transient ischemia may be due to its effects on glucose metabolism. In the absence of transient ischemia, adenosine inhibits glycolysis, whereas it accelerates glycolysis after transient ischemia. Inasmuch as 5'-AMP-activated protein kinase (AMPK) is implicated as a regulator of glucose and fatty acid utilization, this study determined whether a differential alteration of AMPK activity contributes to acceleration of glycolysis by adenosine in hearts stressed by transient ischemia. Studies were performed in working rat hearts perfused aerobically under normal conditions or after transient ischemia (two 10-min periods of ischemia followed by 5 min of reperfusion). LV work was not affected by adenosine. AMPK phosphorylation was not affected by transient ischemia; however, phosphorylation and activity were increased nine- and threefold, respectively, by adenosine in stressed hearts. Phosphorylation of acetyl-CoA carboxylase and rates of palmitate oxidation were unaltered. Glycolysis and calculated proton production were increased 1.8- and 1.7-fold, respectively, in hearts with elevated AMPK activity. Elevated AMPK activity was associated with inhibition of glycogen synthes...Continue Reading

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Citations

Jan 7, 2011·The Journal of Biological Chemistry·Thomas PulinilkunnilBarbara B Kahn
Apr 9, 2014·Canadian Journal of Physiology and Pharmacology·Christopher T LeeGary D Lopaschuk
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May 15, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jagdip S JaswalAlexander S Clanachan
Jan 21, 2010·Physiological Reviews·Gary D LopaschukWilliam C Stanley
Dec 19, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Jagdip S JaswalAlexander S Clanachan
Oct 2, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Karalyn D FolmesJason R B Dyck
Jan 8, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Mohamed A OmarAlexander S Clanachan
May 12, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Clifford D L FolmesGary D Lopaschuk

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