Effects of adenosine on the contractility of normoxic rainbow trout heart

Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
E Aho, Matti Vornanen

Abstract

Temperature strongly affects oxygen solubility in water, oxygen convection in the blood and locomotor activity of the fish. Since oxygen supply and demand are temperature dependent, it was hypothesized that the purinergic control of the heart, one of the most important mediators in oxygen-limited conditions, might also show temperature dependence. Therefore, the present study examines the effects of adenosine (Ado), a purinergic agonist, on the contractile and electrical activity of the thermally acclimated trout ( Oncorhynchus mykiss Walbaum) heart. The fish were acclimated to either 4 degrees C or 17 degrees C and the experiments were conducted at the acclimation temperatures of the animals. In spontaneously beating hearts, Ado had a negative chronotropic and a positive inotropic effect in warm-acclimated rainbow trout while no response was detected in cold-acclimated trout. In paced atrial and ventricular preparations, Ado had a negative inotropic effect in both warm- and cold-acclimated fish, and the response was strongest in the atria of warm-acclimated trout. Ado shortened the duration of contraction 12-14% in atrial preparations but had no effect in ventricular muscle. Ado (10(-4) mol l(-1)) increased the density of the ...Continue Reading

Citations

Feb 19, 2009·Acta Physiologica·G Burnstock, A Verkhratsky
Feb 14, 2014·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·William JoyceTobias Wang
Apr 17, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Jonathan A W StecykAnthony P Farrell
Sep 28, 2016·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Denis V Abramochkin, Matti Vornanen
May 18, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rikke Birkedal, Holly A Shiels
Feb 27, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Isabel A S F CostaA K Gamperl
Sep 18, 2021·The Journal of Experimental Biology·Milica MandicSteve F Perry

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