Effects of adenosine on the functions of circulating polymorphonuclear leukocytes during hyperdynamic endotoxemia.

Infection and Immunity
M ThielK Messmer

Abstract

Endotoxin-activated polymorphonuclear leukocytes (PMNL) adhere to the vascular endothelium and cause damage by the release of toxic superoxide anions (O2-). Because adenosine is a potent inhibitor of PMNL in vitro, the present study investigates the effects of this nucleoside on the functions of circulating PMNL in a standardized porcine model of hyperdynamic endotoxemia. Ten anesthesized pigs received an intravenous (i.v.) 330-min infusion of endotoxin (5 microg/kg of body weight per h). Another 10 pigs were also infused with endotoxin plus adenosine (150 microg/kg/min [i.v.]); this treatment was begun 30 min prior to the beginning of endotoxin treatment. Control groups (five animals per group) received either adenosine or physiological saline. Infusion of endotoxin caused severe neutropenia, shedding of L-selectin, upregulation of beta2-integrins, increased binding of C3-coated zymosan particles, and subsequent phagocytosis by PMNL. While phagocytosis-induced production of oxygen radicals appeared to decrease, extracellular release of superoxide anions was strongly enhanced. Infusion of adenosine during endotoxemia had no effect on neutropenia, expression of adhesion molecules, C3-induced adhesion, phagocytosis, or intracellu...Continue Reading

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Citations

Jan 7, 2004·Critical Care Medicine·Kevin McCallionKeith R Gardiner
Jan 22, 2002·Critical Care Medicine·S KutzscheL J Bjertnaes
Nov 23, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Sang Hyun LimYoshiya Toyoda
Nov 17, 2011·The Journal of Biological Chemistry·Tobias SpeicherAlbrecht Wendel
Mar 17, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Kathryn E BarlettaBorna Mehrad
Nov 11, 2016·Nature Reviews. Rheumatology·Bruce N Cronstein, Michail Sitkovsky

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