Effects of adenosine receptor agonists on nitric oxide release in mouse during endotoxemia

Biochemical Pharmacology
W M HonS Moochhala

Abstract

The effects of adenosine receptor agonists on plasma NOx- (NO2- and NO3-) production in mice treated with lipopolysaccharide (LPS) were investigated. NOx- is the stable decomposition product of nitric oxide (NO), which can be measured as a marker of NO production. Injection of the mice with LPS resulted in increased plasma NOx- concentration, reaching a peak after 8 hr (38 times basal level) and then declining slowly. Pretreatment with the adenosine agonists R-phenylisopropyladenosine (R-PIA), 5'-N-ethylcarboxamidoadenosine (NECA), 5'-(N-cyclopropyl)carboxamidoadenosine (CPCA) and N6-cyclohexyladenosine (CHA) 1 hr before LPS administration caused a dose-dependent reduction of plasma NOx- concentration. The rank order of inhibitory potency was NECA > or = R-PIA > CPCA > CHA, which is characteristic of neither A1 nor A2 receptors.

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Citations

Jun 10, 2000·Artificial Organs·W M HonK H Lee
Mar 15, 1997·Annals of the New York Academy of Sciences·I T Gagalo, M T Matuszek
Jul 19, 2005·Expert Opinion on Investigational Drugs·Courtney M LappasJoel Linden
Oct 7, 2004·European Journal of Pharmacology·Zdenĕk ZídekAntonín Holý
Jun 28, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·C Agnisola

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