Effects of adenovirus-mediated delivery of the human hepatocyte growth factor gene in experimental radiation-induced heart disease

International Journal of Radiation Oncology, Biology, Physics
Shunying HuLi-Sheng Wang

Abstract

Irradiation to the heart may lead to late cardiovascular complications. The purpose of this study was to investigate whether adenovirus-mediated delivery of the human hepatocyte growth factor gene could reduce post-irradiation damage of the rat heart and improve heart function. Twenty rats received single-dose irradiation of 20 Gy gamma ray locally to the heart and were randomized into two groups. Two weeks after irradiation, these two groups of rats received Ad-HGF or mock adenovirus vector intramyocardial injection, respectively. Another 10 rats served as sham-irradiated controls. At post-irradiation Day 120, myocardial perfusion was tested by myocardial contrast echocardiography with contrast agent injected intravenously. At post-irradiation Day 180, cardiac function was assessed using the Langendorff technique with an isolated working heart model, after which heart samples were collected for histological evaluation. Myocardial blood flow was significantly improved in HGF-treated animals as measured by myocardial contrast echocardiography at post-irradiation Day 120 . At post-irradiation Day 180, cardiac function was significantly improved in the HGF group compared with mock vector group, as measured by left ventricular peak...Continue Reading

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Citations

Feb 2, 2012·The British Journal of Radiology·M I Koukourakis
Oct 19, 2010·Cardiology Research and Practice·M Boerma, M Hauer-Jensen
Feb 28, 2015·Cancer Gene Therapy·W H Everett, D T Curiel
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Feb 8, 2018·Human Gene Therapy·Li-Sheng WangChu-Tse Wu
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Oct 17, 2014·Applied Optics·Drew P Kouri, Eric A Shields
Aug 31, 2018·Radiation Oncology·Yue ZhouXiao Zhou
Apr 11, 2020·Drug Design, Development and Therapy·Wen-Bo NieLi-Sheng Wang

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