Effects of Adipocyte Aryl Hydrocarbon Receptor Deficiency on PCB-Induced Disruption of Glucose Homeostasis in Lean and Obese Mice

Environmental Health Perspectives
Nicki BakerLisa A Cassis

Abstract

Coplanar polychlorinated biphenyls (PCBs) promote adipocyte inflammation and impair glucose homeostasis in lean mice. The diabetes-promoting effects of lipophilic PCBs have been observed only during weight loss in obese mice. The molecular mechanisms linking PCB exposures to impaired glucose metabolism are unclear. In this study we tested the hypothesis that coplanar PCBs act at adipocyte aryl hydrocarbon receptors (AhRs) to promote adipose inflammation and impair glucose homeostasis in lean mice and in obese mice during weight loss. PCB-77 administration impaired glucose and insulin tolerance in LF (low fat diet)-fed control (AhR(fl/fl)) mice but not in adipocyte AhR-deficient mice (AhR(AdQ)). Unexpectedly, AhR(AdQ) mice exhibited increased fat mass when fed a standard LF or high fat (HF) diet. In mice fed a HF diet, both genotypes became obese, but AhR(AdQ) mice administered vehicle (VEH) exhibited increased body weight, adipose mass, adipose inflammation, and impaired glucose tolerance compared with AhR(fl/fl) controls. Impairment of glucose homeostasis in response to PCB-77 was not observed in obese mice of either genotype. However, upon weight loss, AhR(fl/fl) mice administered PCB-77 exhibited increased abundance of adipo...Continue Reading

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Citations

Sep 2, 2015·ILAR Journal·Kun LuJames G Fox
Aug 26, 2016·Environmental Health Insights·Cassie Jaeger, Shelley A Tischkau
Aug 4, 2018·The Journal of Endocrinology·Laura MarroquiReinaldo Sousa Dos Santos
Nov 13, 2016·Reviews on Environmental Health·Michael C PetrielloBernhard Hennig
Nov 14, 2019·Environmental Science and Pollution Research International·Francoise A GourroncAloysius J Klingelhutz
Jul 13, 2017·Environmental Science and Pollution Research International·Francoise A GourroncAloysius J Klingelhutz
Apr 25, 2020·Nutrients·Yolanda Gálvez-OntiverosAna Rivas
Dec 19, 2020·International Journal of Environmental Research and Public Health·Brigitte Le Magueresse-Battistoni
Dec 31, 2020·International Journal of Molecular Sciences·Nathaniel G GirerCornelis J Elferink
Aug 28, 2021·International Journal of Molecular Sciences·Iva SovadinováPavel Babica
Aug 22, 2021·Environmental Research·Christopher J MartyniukLorraine Chalifour

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Methods Mentioned

BETA
chip
transgenic
nuclear magnetic resonance
PCR

Software Mentioned

SigmaPlot
NIS Elements
Systat

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