Effects of adjunctive exercise on physiological and psychological parameters in depression: a randomized pilot trial

Journal of Affective Disorders
Arno KerlingKai G Kahl

Abstract

Major depressive disorder (MDD) is associated with decreased physical activity and increased rates of the metabolic syndrome (MetS), a risk factor for the development of type 2 diabetes and cardiovascular disorders. Exercise training has been shown to improve cardiorespiratory fitness and metabolic syndrome factors. Therefore, our study aimed at examining whether patients receiving an exercise program as an adjunct to inpatient treatment will benefit in terms of physiological and psychological factors. Fourty-two inpatients with moderate to severe depression were included. Twenty-two patients were randomized to additional 3x weekly exercise training (EXERCISE) and compared to treatment as usual (TAU). Exercise capacity was assessed as peak oxygen uptake (VO2peak), ventilatory anaerobic threshold (VAT) and workload expressed as Watts (W). Metabolic syndrome was defined according to NCEP ATPIII panel criteria. After 6 weeks of treatment, cardiorespiratory fitness (VO2peak, VAT, Watt), waist circumference and HDL cholesterol were significantly improved in EXERCISE participants. Treatment response expressed as ≥50% MADRS reduction was more frequent in the EXERCISE group. Adjunctive exercise training in depressed inpatients improves...Continue Reading

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Citations

Mar 16, 2016·Journal of Psychiatric Research·Felipe B SchuchBrendon Stubbs
Mar 22, 2016·Journal of Affective Disorders·Matias Carvalho Aguiar MeloVeralice Meireles Sales de Bruin
Oct 9, 2015·PloS One·Tao LiuYanbin Jia
Jun 15, 2016·Sports Medicine·Davy VancampfortBrendon Stubbs
Sep 30, 2016·Der Nervenarzt·L LedochowskiM Kopp
Oct 18, 2018·Depression and Anxiety·Robert StantonSimon Rosenbaum
Mar 9, 2018·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Federica SancassianiAntonio Preti
Apr 26, 2019·International Journal of Environmental Research and Public Health·Hyun Jin LeeWonkyong Song
Aug 8, 2019·Current Sports Medicine Reports·Felipe Barreto Schuch, Brendon Stubbs
Aug 11, 2018·Frontiers in Neuroscience·Cristy Phillips, Atoossa Fahimi
Jul 14, 2020·International Journal of Psychiatry in Clinical Practice·Frank KruisdijkIngrid J M Hendriksen
Jan 9, 2021·Harvard Review of Psychiatry·David S Im
Feb 17, 2021·The Cochrane Database of Systematic Reviews·Masuma Pervin MishuNajma Siddiqi
Dec 8, 2021·European Archives of Psychiatry and Clinical Neuroscience·Peter FalkaiMelanie Heitkamp

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