Effects of adjuvant chemotherapy on recurrence, survival, and quality of life in stage II colon cancer patients: a 24-month follow-up

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Cari LewisKa He

Abstract

The purpose of this cohort study was to investigate the association of adjuvant chemotherapy with quality of life (QoL), survival, and recurrence over the 24 months following diagnosis in stage II colon cancer patients. Overall, 453 patients were recruited from North Carolina from 2009 to 2011 and interviewed with a closed-ended survey detailing quality of life, health behaviors, treatment, and cancer recurrence at three times points: diagnosis, 12-, and 24-months post-diagnosis; mortality was obtained via the National Death Index. In sum, 265 patients received chemotherapy. Receipt of chemotherapy exhibited an inverse association with total Functional Assessment of Cancer Treatment (FACT)-General (P < 0.01), FACT-Colorectal (P < 0.01), physical (P < 0.01), emotional (P = 0.02), and functional (P < 0.01) well-being; the inverse association between receiving chemotherapy and emotional well-being persisted for Caucasians but not African Americans (P interaction = 0.049). Those who received chemotherapy demonstrated significantly higher odds of cancer recurrence (odds ratio (OR) 2.74; 95 % confidence interval (CI) 1.18, 6.35) and all-cause mortality (OR: 1.95; 95 % CI: 1.05, 3.62). In this study, stage II colon cancer patients who...Continue Reading

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Citations

May 12, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·F N van ErningV E P P Lemmens
Jun 18, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Cari LewisKa He
May 17, 2018·Investigación Y Educación En Enfermería·Isadora TrinquinatoAna Lúcia Siqueira Costa Calache
Dec 9, 2017·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Min Ki KimIn Kyu Lee
Jan 31, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C SimillisP P Tekkis
Apr 22, 2018·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Ilufredo Y TantoyChristine Miaskowski
Feb 26, 2016·International Journal of Cancer. Journal International Du Cancer·S R VerhoeffJ F M Pruijt
Feb 16, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·L BatehupJ L Corner
Jan 19, 2021·International Journal of Cancer. Journal International Du Cancer·Gabrielle JongeneelVeerle M H Coupé
Nov 13, 2020·Visceral Medicine·Hossein Taghizadeh, Gerald W Prager

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