PMID: 3762188Oct 1, 1986Paper

Effects of administration routes on the uptake of uridine and 5-fluorouridine into an adenocarcinoma transplanted to rat liver

Journal of Surgical Oncology
C ErichsenU Stenram

Abstract

In a model of secondary liver cancer in Wistar rats, the effect of different administration routes on the uptake of 3H-uridine into tumor and several normal tissues was studied. The rats were inoculated with a tumor cell suspension in the central liver lobe. Ten days later, they were distributed into four groups with a catheter placed in the gastroduodenal artery, the portal vein, one of the femoral veins, or in the peritoneal cavity. 3H-uridine was injected 46 h later and after an additional 90 minutes the animals were anesthetised and pieces of liver tumor and normal tissues were removed and frozen. The incorporation into the acid-soluble fraction and RNA was analyzed. In a separate experiment, 3H-fluorouridine was administered by the gastroduodenal artery and a comparison was made with the uptake of 3H-uridine. A significantly higher amount of uridine was incorporated into the tumor by the arterial route. The intraportal and intraperitoneal routes were comparable, while a somewhat higher incorporation was found by the systemic route. The consequences of using the different routes upon the incorporation into RNA of tumor and dose-limiting organs are demonstrated. With the aid of this experimental model, it is possible to eval...Continue Reading

References

Jan 1, 1983·Journal of Cancer Research and Clinical Oncology·G CarlssonL Hafström
Mar 15, 1980·Cancer·D S MartinT Woodcock
Jan 1, 1956·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J F SCOTTE B TAFT

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Citations

Jan 1, 1985·Journal of Cancer Research and Clinical Oncology·P I ChristenssonU Stenram
Jan 1, 1990·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·I A el HagU Stenram

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