Effects of adolescent exposure to cocaine on locomotor activity and extracellular dopamine and glutamate levels in nucleus accumbens of DBA/2J mice

Brain Research
Rosana CamariniM F Olive

Abstract

Adolescents differ from adults in their acute sensitivity to several drugs of abuse, but little is known about the long-term neurobehavioral effects of adolescent drug exposure. To explore this further, we evaluated the locomotor responses to repeated cocaine administration in adolescent and adult male DBA/2J mice and alterations in extracellular levels of dopamine (DA) and glutamate (GLU) in the nucleus accumbens (NAc) in response to a subsequent cocaine challenge. Adolescent and adult mice were treated daily with saline or cocaine (10 mg/kg, i.p) for 9 consecutive days. Ten days following the last injection, animals were implanted with microdialysis probes and 24 h later microdialysis samples were collected before and after an acute cocaine challenge. Adolescents but not adults demonstrated development of behavioral sensitization to cocaine. Microdialysis procedures revealed that cocaine-treated mice displayed greater peak increases in extracellular DA in response to a subsequent cocaine challenge as compared to saline-treated mice, in contrast with lower peak increases in extracellular GLU. While adults exhibited greater peaks in extracellular DA in response to cocaine than adolescents did, adolescent mice presented a more r...Continue Reading

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Citations

Jun 24, 2009·Psychopharmacology·Nicole L Schramm-SapytaCynthia M Kuhn
Jul 4, 2012·Psychopharmacology·Natalie E ZlebnikMarilyn E Carroll
Apr 9, 2010·Alcoholism, Clinical and Experimental Research·Ricardo M PautassiYedy Israel
Apr 21, 2016·Brain Research Bulletin·Rosana Camarini, Ricardo Marcos Pautassi
Feb 1, 2011·Pharmacology, Biochemistry, and Behavior·Sonia R KamedaRoberto Frussa-Filho
Dec 28, 2010·Pharmacology, Biochemistry, and Behavior·Rosana CamariniHelena Maria Calil
Jan 21, 2014·Neuropharmacology·Joana GonçalvesAna Paula Silva
Apr 8, 2017·Frontiers in Behavioral Neuroscience·Priscila F Carrara-NascimentoRosana Camarini
Mar 27, 2020·Frontiers in Behavioral Neuroscience·Priscila Fernandes Carrara-NascimentoRosana Camarini

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