Effects of adopting the Global Lung Function Initiative 2017 reference equations on the interpretation of carbon monoxide transfer factor.

The European Respiratory Journal
Danny J BrazzaleWarren R Ruehland

Abstract

The recently published Global Lung Function Initiative (GLI) carbon monoxide transfer factor (T LCO) reference equations provide an opportunity to adopt a current, all-age, widely applicable reference set. The aim of this study was to document the effect of changing to GLI from commonly utilised reference equations on the interpretation of T LCO results.33 863 T LCO results (48% female, 88% Caucasian, n=930 aged <18 years) from clinical pulmonary function laboratories within three Australian teaching hospitals were analysed. The lower limit of normal (LLN) and proportion of patients with a T LCO below this value were calculated using GLI and other commonly used reference equations.The average T LCO LLN for GLI was similar or lower than the other equations, with the largest difference seen for Crapo equations (median: -1.25, IQR: -1.64, -0.86 mmol·min-1·kPa-1). These differences resulted in altered rates of reduced T LCO for GLI particularly for adults (+1.9% versus Miller to -27.6% versus Crapo), more so than for children (-0.8% versus Kim to -14.2% versus Cotes). For adults, the highest raw agreement for GLI was with Miller equations (94.7%), while for children it was with Kim equations (98.1%). Results were reclassified from ...Continue Reading

References

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Sep 30, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Danny J BrazzaleJeffrey J Pretto
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
Oct 19, 2011·The European Respiratory Journal·Helen WardMartin R Miller
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May 2, 2012·The European Respiratory Journal·Jane KirkbyJanet Stocks
Mar 23, 2013·The European Respiratory Journal·Philip H QuanjerJeffrey J Pretto
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Feb 4, 2014·The European Respiratory Journal·Martin R MillerTorben Sigsgaard
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Jan 28, 2017·American Journal of Respiratory and Critical Care Medicine·Claus F VogelmeierAlvar Agustí
Sep 13, 2017·The European Respiratory Journal·Sanja StanojevicUNKNOWN Global Lung Function Initiative (GLI) TLCO

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Citations

Mar 13, 2021·The European Respiratory Journal·Graham L HallUNKNOWN contributing GLI Network members
Apr 13, 2021·Frontiers in Physiology·Justine Frija-MassonMarie-Pia d'Ortho

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