Effects of adrenal dysfunction and high-dose adrenocorticotropic hormone on NMDA-induced spasm seizures in young Wistar rats

Epilepsy Research
Ya-Jie WangLi-Ping Zou

Abstract

Infantile spasms (IS) is a devastating epilepsy syndrome treated with adrenocorticotropic hormone (ACTH). To demonstrate the effects of adrenal dysfunction, adrenalectomy (ADX) and N-methyl-d-aspartate (NMDA)-induced rat model studies of IS were performed. The latency of the seizure in the ADX group decreased and the severity of seizures increased significantly. Hippocampal corticotropin-releasing hormone (CRH) mRNA was overexpressed in ADX rats. After ACTH administration, the latency increased and the severity of seizures decreased significantly. ADX increased seizure susceptibility of the rats to NMDA. Pretreatment with a single high dose of ACTH caused an obvious reduction in susceptibility to NMDA-induced seizures and suppressed CRH mRNA expression. These findings are especially useful for IS patients with adrenal diseases and worthy of further clinical study.

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Citations

Mar 19, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Carlos A PardoAristea S Galanopoulou
Jul 6, 2014·Epilepsy Research·Jing WangLi-Ping Zou
May 9, 2015·Molecular Medicine Reports·Guang YangFei-Yong Jia
Oct 23, 2013·Epilepsy & Behavior : E&B·Jolien S van CampenMarian Joels
Jan 15, 2013·Brain & Development·Aristea S Galanopoulou
Nov 26, 2015·Epilepsy Research·Xiu-Yu ShiLi-Ping Zou
Aug 22, 2016·Seminars in Pediatric Neurology·Li-Rong Shao, Carl E Stafstrom
Apr 20, 2018·Current Neurology and Neuroscience Reports·Sarah Aminoff Kelley, Kelly G Knupp
Apr 23, 2020·Expert Review of Neurotherapeutics·Nicola SpecchioPaolo Curatolo

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