Sep 17, 2013

Effects of adrenaline on rhythm transitions in out-of-hospital cardiac arrest

Acta Anaesthesiologica Scandinavica
Andres NesetTheresa M Olasveengen

Abstract

We wanted to study the effects of intravenous (i.v.) adrenaline (epinephrine) on rhythm transitions during cardiac arrest with initial or secondary ventricular fibrillation/tachycardia (VF/VT). Post hoc analysis of patients included in a randomised controlled trial of i.v. drugs in adult, non-traumatic out-of-hospital cardiac arrest patients who were defibrillated and had a readable electrocardiography recording. Patients who received adrenaline were compared with patients who did not. Cardiac rhythms were annotated manually using the defibrillator data. Eight hundred and forty-nine patients were included in the randomised trial of which 223 were included in this analysis; 119 in the adrenaline group and 104 in the no-adrenaline group. The proportion of patients with one or more VF/VT episodes after temporary return of spontaneous circulation (ROSC) was higher in the adrenaline than in the no-adrenaline group, 24% vs. 12%, P = 0.03. Most relapses from ROSC to VF/VT in the no-adrenaline group occurred during the first 20 min of resuscitation, whereas patients in the adrenaline group experienced such relapses even after 20 min. Fibrillations from asystole or pulseless electrical activity, shock resistant VF/VT and the number of r...Continue Reading

  • References23
  • Citations10

References

  • References23
  • Citations10

Citations

Mentioned in this Paper

Ventricular Fibrillation
Adrenalin
Fibrillation
Cardiac Rhythm Type
Epinephrine Measurement
Medihaler-Epi
Tachycardia, Ventricular
Electrocardiography
Electroversion Therapy
Epinephrine

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.