PMID: 40389Aug 1, 1979

Effects of adrenergic beta-blockers and a membrane stabilizing agent on ouabain-induced cardiac arrhythmias in anaesthetized guinea pigs

Acta Pharmacologica Et Toxicologica
G AbergE Telemo


The antiarrhythmic effects of dl'propranolol, d-propranolol, metoprolol and lidocaine against ouabain-induced cardiac arrhythmias were studied. It was found that contrary to earlier findings in the dog, the effects of the adrenergic beta-blockers against ouabain-arrhythmias in guinea pigs were due to beta-blocking activity and not the membrane-stabilizing activity of the compounds. The cardioselective beta-blocker, metoprolol, was more or equally effective as dl-propranolol against ouabain-induced arrhythmias in guinea pigs.


Feb 1, 1973·Life Sciences. Pt. 1: Physiology and Pharmacology·B AbladL Ek
Sep 1, 1966·The American Journal of Cardiology·E M WILLIAMS
Jun 1, 1969·British Journal of Pharmacology·A N DohadwallaE M Vaughan Williams
Jun 25, 1966·Nature·R Howe, R G Shanks

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Anti-Arrhythmia Agents
Antiarrhythmic [EPC]
Lidocaine Measurement
Lidocaine Monohydrochloride, Monohydrate

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