Effects of adrenoceptor agonists and antagonists on morphine-induced Straub tail in mice

Pharmacology, Biochemistry, and Behavior
Mohammad-Reza ZarrindastMaryam Ghadimi

Abstract

Straub-tail behavior was induced by subcutaneous injection of different doses (10-60 mg/kg) of morphine to mice. The maximum response was obtained with 20-40 mg/kg of the drug. The response induced by morphine (40 mg/kg) was decreased by intraperitoneal administration of different doses of clonidine (0.05-0.1 mg/kg). Pretreatment of animals with yohimbine (1-4 mg/kg i.p.) reversed the inhibitory action of clonidine. Yohimbine did not elicit any response by itself. Administration of prazosin (0.25, 0.5, and 1 mg/kg) reduced the morphine response. The combination of prazosin with yohimbine (1 mg/kg), but not with clonidine (0.05 mg/kg), caused a potentiated inhibition of the morphine effect. Phenylephrine (2-6 mg/kg i.p.) did not elicit any effect by itself and also did not alter the response induced by morphine or morphine plus clonidine. Dobutamine (2.5-10 mg/kg i.p.), atenolol (2.5-10 mg/kg i.p.), salbutamol (2.5-10 mg/kg i.p.), and propranolol (2.5-10 mg/kg i.p.) did not alter morphine-induced Straub-tail behavior in mice. In conclusion, activation of alpha2-adrenergic pathways contributes to morphine-induced Straub tail, while alpha1- and beta2-adrenergic may not be involved in this phenomenon.

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Citations

Nov 13, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Dec 2, 2010·The Journal of Pharmacology and Experimental Therapeutics·John J LoweryEdward J Bilsky
Oct 30, 2016·European Journal of Pharmacology·Irina V BelozertsevaAnton Yu Bespalov
Mar 28, 2008·The Journal of Pharmacology and Experimental Therapeutics·Nicolas P LapointePierre A Guertin
Jun 27, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Olivia Rose StephensSerpil C Erzurum

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