Effects of adrenomedullin on cell proliferation in rat adventitia induced by aldosterone

Journal of Hypertension
Wei JiangChao-Shu Tang

Abstract

Aldosterone is involved in cardiovascular diseases such as hypertension and heart failure by inducing sodium retention and vascular remodeling, which is characterized by fibroblast proliferation and migration in adventitia. It is well known that aldosterone stimulates vascular smooth muscle cells and fibroblasts to produce and secrete adrenomedullin (ADM), a multiple functional peptide with an important cytoprotective effect against cardiovascular damage. We examined the effect of aldosterone on ADM production and secretion and its mRNA expression in rat aortic adventitia to study the paracrine/autocrine interaction between endogenous ADM and aldosterone. ADM produced and secreted from adventitia stimulated by aldosterone in the absence or presence of spironolactone, RU486 or spironolactone together with RU486 were detected by radioimmunoassay, proliferation in adventitia cells was evaluated by the level of [H]-thymine incorporation, and preproADM gene expression was measured by semi-quantitative reverse transcriptase polymerase chain reaction. Adventitial ADM secretion and mRNA expression stimulated by aldosterone were concentration-dependent as was the inhibitive effect of ADM on aldosterone-induced proliferation. The inducti...Continue Reading

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Citations

Feb 13, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshihiro KitaKazuo Kitamura
Sep 6, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Johji KatoTanenao Eto
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Mar 3, 2007·Journal of Applied Physiology·Hiroshi YamamotoYasuyoshi Ouchi
Dec 20, 2017·Molecular Medicine Reports·Jun LiShu-Yi Dang

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