Effects of Adrenomedullin on Doxorubicin-Induced Cardiac Damage in Mice

Biological & Pharmaceutical Bulletin
Takahiro YoshizawaKiyoshi Matsumoto

Abstract

Doxorubicin (DOX) is one of the best known anticancer drugs, and is used in the treatment of lymphoma, lung cancer, stomach cancer, and a number of other cancers. However, DOX has some serious side effects, the worst being lethal heart failure. Occasionally, its side effects result in the cessation of the anticancer treatment, thus having a serious adverse influence on prognosis. Agents that can be administered as alternative prophylactics or to ameliorate the side effects of DOX will be useful in increasing the safety and efficacy of anticancer therapy. Adrenomedullin (AM) is a peptide hormone secreted by many organs, including the heart; it has an organ-protective effect, including antiapoptotic, anti-inflammatory, and antioxidative stress. Blood AM levels increase with heart failure; endogenic AM has been suggested in order to protect the heart. Furthermore, exogenous AM administration has shown therapeutic effects for heart failure in patients. However, it is unclear whether AM can protect the heart against drug-induced cardiac injury in vivo. The present study was performed in order to investigate the effects of AM on DOX-induced cardiac damage. Male BALB/c mice were treated with DOX and/or AM. Exogenous AM improved the su...Continue Reading

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Citations

Mar 10, 2018·Frontiers in Immunology·Christopher GevenPeter Pickkers
Sep 1, 2018·Proceedings of the National Academy of Sciences of the United States of America·Svenja HinrichsDiana Lindner
Dec 29, 2018·European Journal of Heart Failure·Adriaan A VoorsJaved Butler
Jan 4, 2021·Cardiovascular Toxicology·Gulcin DurdagiMustafa Ozbek
Dec 2, 2020·Expert Opinion on Investigational Drugs·Benjamin DeniauAlexandre Mebazaa

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