Effects of adult dysthyroidism on the morphology of hippocampal neurons

Behavioural Brain Research
Josefina Sala-RocaMaria Assumpció Martí-Carbonell

Abstract

This study investigates the effect of thyroid hormones on the morphology of hippocampal neurons in adult rats. Hypo- and hyperthyroidism were induced by adding 0.02% methimazole and 1% l-thyroxine, in drinking water from 40 days of age, respectively. When the rats were 89 days old their brains were removed and stained by a modified Golgi method and blood samples were collected in order to measure T4 serum levels. Neurons were selected and drawn using a camera lucida. Our results show that methimazole administration reduces the dendritic branching of the apical shafts of CA3 and CA1 pyramidal neurons mainly by increasing the distance to the first branch point in both types of neurons, and reducing branch points in the radius of 50 microm from the soma in CA1 neurons. Nevertheless, it was observed an increase of apical spine density in CA3 neurons from this group. Thyroxine reduces apical and basal tree of CA3 pyramidal neurons increasing the distance to the first branch point, reducing branch points in the radius of 50 microm from the soma and increases their apical and basal spine density. In CA1 field, thyroxine reduces the number of basal branch points. Both treatments seems to provoke alterations in the same direction reduci...Continue Reading

Citations

Jan 5, 2014·Oxidative Medicine and Cellular Longevity·I VillanuevaJ Pacheco-Rosado
Jan 19, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mal-Soon ShinBaek-Vin Lim
Jun 6, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·O M AhmedS M Abd El-Tawab
Jan 17, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Glaecir Roseni Mundstock DiasNilda Berenice de Vargas Barbosa
Jul 21, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ibtissem Ben AmaraNajiba Zeghal
Dec 11, 2008·Neurotoxicology and Teratology·L L DriscollA Hieb
Mar 16, 2016·Thyroid : Official Journal of the American Thyroid Association·Yong-Wook ShinWon Bae Kim
Dec 21, 2011·Journal of Neuroscience Research·K B Sánchez-HuertaJ Pacheco-Rosado
May 12, 2009·Neuroscience Letters·Claudia Alva-SánchezJorge Pacheco-Rosado

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