Effects of aerobic exercise on vascular function in nondialysis chronic kidney disease: a randomized controlled trial

American Journal of Physiology. Renal Physiology
Danielle L KirkmanDavid G Edwards

Abstract

Endothelial dysfunction and arterial stiffness are nontraditional risk factors of chronic kidney disease (CKD)-related cardiovascular disease (CVD) that could be targeted with exercise. This study investigated the effect of moderate to vigorous aerobic exercise on vascular function in nondialysis CKD. In this randomized, controlled trial, 36 nondialysis patients with CKD (means ± SE, age: 58 ± 2 yr, estimated glomerular filtration rate: 44 ± 2 ml·min-1·1.73 m-2) were allocated to an exercise training (EXT) or control (CON) arm. The EXT group performed 3 × 45 min of supervised exercise per week at 60-85% heart rate reserve for 12 wk, whereas the CON group received routine care. Outcomes were assessed at 0 and 12 wk. The primary outcome, microvascular function, was assessed via cutaneous vasodilation during local heating measured by laser-Doppler flowmetry coupled with microdialysis. Participants were instrumented with two microdialysis fibers for the delivery of 1) Ringer solution and 2) the superoxide scavenger tempol. Conduit artery function was assessed via brachial artery flow-mediated dilation. Aortic pressure waveforms and pulse wave velocity were acquired with tonometry and oscillometry. Microvascular function improved af...Continue Reading

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Citations

Jul 24, 2020·Current Opinion in Nephrology and Hypertension·Thomas J WilkinsonUNKNOWN Global Renal Exercise Network
Jun 13, 2020·American Journal of Hypertension·Seiji ItanoNaoki Kashihara
Mar 29, 2021·European Journal of Clinical Investigation·Marieta P TheodorakopoulouPantelis Sarafidis
Apr 10, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Danielle L KirkmanDavid G Edwards
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Dec 15, 2020·Annals of Physical and Rehabilitation Medicine·Danielle L KirkmanDavid G Edwards
Nov 3, 2021·Journal of Cardiopulmonary Rehabilitation and Prevention·Brittany OverstreetSteven J Keteyian
Dec 12, 2021·Journal of the American Society of Nephrology : JASN·Kassia S BeethamErin J Howden

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Clinical Trials Mentioned

NCT02050035

Software Mentioned

Labview
SPSS

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