PMID: 3748336Jul 1, 1986Paper

Effects of aerosolized methylprednisolone on experimental neurogenic pulmonary injury

Neurosurgery
H L EdmondsG Dahlquist

Abstract

We examined the effects of graded doses of methylprednisolone sodium succinate (MPSS)--0.05 (low), 0.5 (medium), and 5 mg/kg/hour (high)--on the development of neurogenic pulmonary injury in rabbits. The aerosolized drug was administered intratracheally for 5 hours beginning 10 minutes after a 2-minute elevation of the cerebrospinal fluid pressure (Pcsf) to 250 mm Hg. Compared to untreated control animals, the percentage of increase in pulmonary capillary permeability, as determined by 51Cr-labeled ethylenediaminetetraacetic acid clearance, was significantly less in the low and high dose MPSS groups. However, high dose MPSS was also associated with a significant decrease in compliance and increase in tissue hemorrhage (quantified by visual inspection). These results indicate biphasic effect of MPSS on alveolar capillary integrity after elevated Pcsf. The low dose minimized the extent of lung hemorrhage, pulmonary capillary leakage, and loss of lung compliance. In contrast, the high dose accelerated tissue hemorrhage and compliance loss, even though pulmonary capillary permeability was maintained near base line rates.

Citations

Jun 28, 2003·Transplantation·Vassilios S AvlonitisJohn H Dark
Nov 20, 2009·Medicina intensiva·J M Domínguez-RoldánJ J Egea Guerrero
Feb 24, 2006·Heart, Lung & Circulation·Erkan YildirimKamer Kilinc
Jun 13, 2015·Critical Care Medicine·Katharina M Busl, Thomas P Bleck
Jan 1, 1987·Neuroscience and Biobehavioral Reviews·A WauquierG H Clincke
Jan 18, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·V S AvlonitisJ H Dark
Mar 12, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Vassilios S AvlonitisJohn H Dark
Dec 1, 2020·PloS One·Judith E van ZandenMaximilia C Hottenrott

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