Effects of Agaricus brasiliensis mushroom in Walker-256 tumor-bearing rats

Canadian Journal of Physiology and Pharmacology
Fernanda Menon Dias JumesAlexandra Acco

Abstract

Agaricus brasiliensis is a mushroom native to São Paulo State, Brazil, that is studied for its medicinal proprieties. This work aimed to investigate the antitumoral activity of A. brasiliensis extracts and pure powdered basidiocarp preparation using Walker-256 (W256) tumor-bearing rats, a model for cancer-related cachexia studies. The rats were treated for 14 days by gavage (136 mg/kg) and at the end of the experiment tumors were collected to calculate mass and volume. Blood was collected for determination of plasma glucose, albumin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Hepatic and tumor enzymes indicating oxidative stress were also evaluated. The results showed that all 4 treatments (pure powdered basidiocarp and aqueous, acid, and alkaline extracts) significantly reduced tumor size and promoted gain in body weight. Plasmatic analysis showed a reduction in AST level and increased glycemia in the treated rats. Pure basidiocarp preparations improved the liver catalase and superoxide dismutase activity, but did not change the glutathione S-transferase activity. The data collected from the W256 tumor-bearing rats revealed the beneficial effects of A. brasiliensis in tumor treatment, mainly related ...Continue Reading

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Citations

Apr 29, 2014·World Journal of Microbiology & Biotechnology·Míria Benetati Delgado BertéliNelson Barros Colauto
May 23, 2014·World Journal of Microbiology & Biotechnology·Thiago Pereira SouzaEustáquio Souza Dias
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Mar 19, 2013·Acta Cirúrgica Brasileira·Nara Macedo BotelhoJuarez Antônio Simões Quaresma

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