PMID: 2509824Jan 1, 1989Paper

Effects of age and breed on the phospholipid composition of canine surfactant

Lung
C ClercxL M van Golde

Abstract

To investigate possible age- and breed-related changes in the composition of canine pulmonary surfactant, we determined the phospholipid patterns of surfactants isolated by bronchoalveolar lavage of 3 age categories of beagles (3-7 months; 3-7 years; 12 years and older) and of 1 group of greyhounds (4-14 years). There was a significant (p = 0.01) increase in the proportion of phosphatidylcholine in surfactant with age, whereas the proportions of phosphatidylserine and sphingomyelin were significantly lower in old beagles compared to young dogs. Although the differences were generally rather small, they may nevertheless be of biological importance, as was indicated by comparing the minimal surface tensions of lavage fluids obtained from young and old beagles. It is attractive to speculate that the shift in surfactant lipid composition could be 1 of the mechanisms that permit efficient lung function in old dogs, despite changes in morphology and mechanics in the aging lung. The phospholipid composition of surfactant isolated from greyhounds differed significantly from that in beagles. The surfactant of greyhounds was enriched in phosphatidylglycerol compared to all age groups of beagles. The degree of saturation of surfactant pho...Continue Reading

References

Jul 1, 1977·Journal of Gerontology·S YasuokaE Tsubura
Sep 1, 1978·The Tohoku Journal of Experimental Medicine·T AkinoK Ohno
Apr 1, 1988·Physiological Reviews·L M Van GoldeB Robertson
Apr 1, 1987·Radiology·J W GurneyS I Rennard
Sep 1, 1972·The American Journal of Physiology·R J King, J A Clements
Aug 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S L YoungG W Brumley
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

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Citations

Apr 7, 1993·Molecular and Cellular Biochemistry·S K DasS Mukherjee
Aug 4, 2009·Journal of Veterinary Internal Medicine·U ChristmannV A Buechner-Maxwell
Aug 26, 2015·Journal of Veterinary Emergency and Critical Care·Liege Garcia SilvaCamila Infantosi Vannucchi
Apr 12, 2016·Metabolomics : Official Journal of the Metabolomic Society·Amanda J LloydDavid Allaway

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