Effects of age and diabetes on scleral stiffness

Journal of Biomechanical Engineering
Baptiste CoudrillierThao D Nguyen

Abstract

The effects of diabetes on the collagen structure and material properties of the sclera are unknown but may be important to elucidate whether diabetes is a risk factor for major ocular diseases such as glaucoma. This study provides a quantitative assessment of the changes in scleral stiffness and collagen fiber alignment associated with diabetes. Posterior scleral shells from five diabetic donors and seven non-diabetic donors were pressurized to 30 mm Hg. Three-dimensional surface displacements were calculated during inflation testing using digital image correlation (DIC). After testing, each specimen was subjected to wide-angle X-ray scattering (WAXS) measurements of its collagen organization. Specimen-specific finite element models of the posterior scleras were generated from the experimentally measured geometry. An inverse finite element analysis was developed to determine the material properties of the specimens, i.e., matrix and fiber stiffness, by matching DIC-measured and finite element predicted displacement fields. Effects of age and diabetes on the degree of fiber alignment, matrix and collagen fiber stiffness, and mechanical anisotropy were estimated using mixed effects models accounting for spatial autocorrelation. ...Continue Reading

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Citations

Apr 7, 2016·Dermatology Research and Practice·Stéphane Chabaud, Stéphane Bolduc
Jun 28, 2015·Experimental Eye Research·Thao D Nguyen, C Ross Ethier
Aug 27, 2015·Annals of Biomedical Engineering·M Á Ariza-GraciaJ F Rodríguez-Matas
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May 15, 2020·Investigative Ophthalmology & Visual Science·Andrew J FeolaC Ross Ethier
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Jan 15, 2020·Eye·Ruti SellaNatalie A Afshari
Mar 23, 2018·Biomechanics and Modeling in Mechanobiology·Julio Flecha-LescúnMiguel Ángel Ariza-Gracia
Nov 6, 2020·Investigative Ophthalmology & Visual Science·Diane N SayahMark R Lesk
Aug 15, 2019·Progress in Retinal and Eye Research·Craig BooteMichael J A Girard
Apr 19, 2021·Clinical & Experimental Ophthalmology·Leyla JabbarliNikolaos E Bechrakis
Jul 31, 2021·Current Eye Research·Hamed Hatami-Marbini, Mohammad Pachenari

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