PMID: 15374299May 1, 1994Paper

Effects of age and dietary restriction on liver glutathione transferase activities in Lobund-Wistar rats

Archives of Gerontology and Geriatrics
L H ChenD L Snyder

Abstract

Glutathione-S-transferases (GST) are a group of enzymes which detoxify electrophilic xenobiotics (including drugs, carcinogens and their metabolites), and thus may be involved in the age-related pathologic process. Effects of a 30% dietary restriction on liver GST activities toward seven substrates were studied in male Lobund-Wistar (L-W) rats at 6, 12, 18, 24 and 30 months of age. The enzyme activities in the ad libitum (AL) group toward 1-chloro-2,4-dinitrobenzene (CDNB), bromosulfophthalein (BSP), 4-nitropyridine-N-oxide (NPNO), p-nitrobenzyl chloride (NBC), trans-4-phenyl-3-buten-2-one (PBO) and styrene oxide (STOX) did not change with age, while those toward 1,2-dicholoro-4-nitrobenzene (DCNB) decreased after middle age. The enzyme activities in the dietary restricted (DR) group toward CDNB and STOX did not change with age, while those toward DCNB, BSP, NPNO, NBC and PBO decreased after middle age. The DR group had significantly higher GST activities than the AL group, especially at 18 months, when BSP, NPNO, NBC and PBO were used as the substrates. Dietary restriction did not affect GST activities toward all seven substrates at old age. These results are substrate-specific, indicating that isozyme-specific changes in GST ...Continue Reading

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Citations

Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kevin J PearsonRafael de Cabo
Jul 9, 2013·Experimental Gerontology·Holly M Brown-Borg, Sharlene Rakoczy
Jun 10, 2016·Phytotherapy Research : PTR·Saeed SamarghandianTahereh Farkhondeh
Nov 20, 2015·Oxidative Medicine and Cellular Longevity·Danielle R BrunsKaryn L Hamilton
Dec 22, 2007·The Journal of Pharmacology and Experimental Therapeutics·Albert L ShroadsPeter W Stacpoole
Apr 4, 2020·Antioxidants & Redox Signaling·Aleksandra Mladenovic DjordjevicEfstathios S Gonos
Aug 25, 2005·Experimental Biology and Medicine·Morris Pollard, Mark A Suckow
Feb 20, 2019·Frontiers in Pharmacology·Andrea Rodrigues VasconcelosCarolina Demarchi Munhoz

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