Effects of age and gender on shortening velocity and myosin isoforms in single rat muscle fibres

Acta Physiologica Scandinavica
H DegensL Larsson

Abstract

The maximum velocity of unloaded shortening (V0) and the myosin heavy chain (MyHC) and light chain (MyLC) isoform composition were determined in single fibres from soleus and extensor digitorum longus (EDL) muscles of male and female rate 3-6 and 22-24 months old. In the soleus muscle, the beta/slow (type I MyHC) isoform predominated in both young and old animals, irrespective of gender. In the EDL, fibres expressing type IIX MyHC or a combination of IIX and IIB (IIXB) MyHC isoforms were predominant in old rats, while type IIB MyHC fibres predominated in young individuals of both genders. The V0 of soleus fibres expressing the type I MyHC isoform decreased (P < 0.001) by 40% with age in spite of an unchanged MyLC composition. In the EDL, the V0 of fibres expressing IIX, IIXB and IIB MyHC isoforms did not changes with age or differ between males and females. In conclusion, similar age-related changes in V0 and MyHC composition were observed in single muscle cells from both male and female rats. The present results demonstrate that the relationship between V0 and MyHC isoform composition at the single fibre level is similar in male and female rats, and that similar qualitative changes take place during ageing in both genders.

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Citations

Oct 30, 2003·Aging Clinical and Experimental Research·Jennifer FoxLadora V Thompson
Dec 2, 2010·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Sally F GilliverHans Degens
Oct 24, 2001·Experimental Gerontology·M PoussonJ Van Hoecke
Nov 20, 2010·Exercise and Sport Sciences Reviews·Adamantios ArampatzisJörn Rittweger
Apr 26, 2005·American Journal of Respiratory and Critical Care Medicine·Coen A C OttenheijmP N Richard Dekhuijzen
Jan 7, 2010·Biomedical Research·Hidetaka ImagitaHirofumi Miyata
Aug 11, 2010·Pflügers Archiv : European journal of physiology·Hans DegensRob C I Wüst
Aug 21, 2007·Experimental Gerontology·Ewa ProchniewiczDavid D Thomas
Feb 17, 2009·Experimental Physiology·Jamie S McPheeDavid A Jones
Jul 30, 2009·Experimental Physiology·S F GilliverD A Jones
Mar 14, 2003·Muscle & Nerve·Hans Degens, Stephen E Alway
Oct 20, 2004·Mechanisms of Ageing and Development·Dawn A LoweLaDora V Thompson
Aug 2, 2011·The Journal of Toxicological Sciences·Hisakuni ObayashiAtsushi Sanbuissho
May 16, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Stephen E AlwayJunaith S Mohamed
Apr 17, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Boštjan ŠimunicHans Degens
Nov 15, 2018·Physiological Reviews·Lars LarssonMarco Sandri
Oct 24, 2008·American Journal of Physiology. Cell Physiology·O AgbulutA Ferry
Apr 11, 2009·Journal of Applied Physiology·Thomas L Clanton, Sanford Levine
Feb 14, 2012·Intensive Care Medicine·Hieronymus W H van HeesLeo M A Heunks
Jun 11, 2002·American Journal of Physiology. Cell Physiology·Dawn A LoweLaDora V Thompson
Jun 11, 2002·American Journal of Physiology. Cell Physiology·Stephen E AlwayCheryl A Smith
Jun 12, 2001·American Journal of Physical Medicine & Rehabilitation·L S KrivickasW R Frontera
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·B RamamurthyL Larsson
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·H DegensM Van Bilsen
May 13, 2006·Journal of Applied Physiology·Sheng ZhongLaDora V Thompson
May 12, 2009·American Journal of Physiology. Heart and Circulatory Physiology·R C I WüstH Degens
Mar 14, 2001·American Journal of Physiology. Cell Physiology·P HöökL Larsson
Sep 17, 2019·Journal of Exercise Rehabilitation·Yunah JeonSeung-Jun Choi
Aug 23, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Coen A C OttenheijmP N Richard Dekhuijzen
Nov 22, 2000·Drugs & Aging·L Larsson, B Ramamurthy

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