Effects of age and prolonged running on proteolytic capacity in mouse cardiac and skeletal muscles

Acta Physiologica Scandinavica
A Salminen, V Vihko

Abstract

Male NMRI-mice, aged 3, 6, 9, and 12 months, were made to run for a period of 4 4 at a speed of 13.5 m/min on a motor-driven treadmill, 5 days after exertion, selected enzymatic estimates of acid and alkaline proteolytic as well as energy metabolic capacities were analyzed from the cardiac muscle and from the red and white parts of m. quadriceps femoris (MQF). The activities of alkaline and myofibrillar proteases increased most considerably in skeletal muscles with age. Cathepsin D and beta-glucuronidase activities were less affected in both muscles. Prolonged running increased the activities of cathepsin D, dipeptidyl aminopeptidase I and beta-glucuronidase in the white and, especially in the red part of MQF. This stimulation of acid hydrolytic capacity was more prominent at the ages of 3 and 6 months than in the older animals. The estimates of alkaline proteolytic or energy metabolic capacities were not affected by prolonged running. In cardiac muscle, no significant changes were recorded in acid hydrolytic or energy metabolic capacity. Histological observation showed no necrosis or other pathological phenomena in the proximal part of m. rectus femoris after excretion. We suggest that the increased acid proteolytic capacity i...Continue Reading

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Citations

Jan 1, 1988·European Journal of Applied Physiology and Occupational Physiology·M KihlströmV Vihko
Jan 1, 1984·European Journal of Applied Physiology and Occupational Physiology·A SalminenV Vihko
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A Salminen, V Marjomäki
Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·A SalminenV Vihko
Jan 1, 1988·Acta histochemica·R ColemanM Silbermann
Nov 1, 1983·Acta Physiologica Scandinavica·A SalminenV Vihko
Oct 1, 1983·Muscle & Nerve·A Salminen, V Vihko
Sep 1, 1987·JPEN. Journal of Parenteral and Enteral Nutrition·G F GuarnieriA Zanettovich
Sep 25, 2001·Journal of Applied Physiology·N StupkaS M Phillips
May 11, 2004·Journal of Applied Physiology·Yutaka KanoTimothy I Musch

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