Effects of age and resistance exercise on skeletal muscle interstitial prostaglandin F(2alpha)

Prostaglandins, Leukotrienes, and Essential Fatty Acids
Todd TrappeRobert Hickner

Abstract

Prostaglandin (PG) F2alpha has been shown to contribute to the anabolic events in skeletal muscle. We measured the skeletal muscle interstitial concentration of PGF2alpha at rest and following a standard bout of resistance exercise in eight young (27+/-2 year) and eight old (75+/-4 year) men. Interstitial PGF2alpha concentration was determined from microdialysate samples obtained from two microdialysis probes placed in the vastus lateralis. Microdialysates were collected 1h pre- and 5-6, 8-9, and 24-25 h postexercise. The exercise bout consisted of 4 exercises (3 sets of 8 replications at 80% 1 RM per exercise) emphasizing the quadriceps. Interstitial PGF2alpha levels were not different (P>0.05) between young and old at rest (1.50+/-0.35 vs. 1.52+/-0.30 ng ml-1) or at any time point following the resistance exercise bout. For the young and old combined there was a change (P<0.05) in PGF2alpha levels at 5-6 h (93%) and 8-9 h (95%), which had returned to preexercise levels by 24-25 h. These results show that PGF2alpha is increased in skeletal muscle following a standard bout of resistance exercise and aging does not alter interstitial levels of this PG at rest or after exercise. These data, coupled with previous findings, suggest...Continue Reading

References

Jan 1, 1991·Pharmacology & Therapeutics·W L SmithD L DeWitt
Feb 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R M Palmer
Apr 15, 1982·The Biochemical Journal·R F Irvine
Jan 20, 1994·Nature·J Vane
Jan 1, 1997·Annual Review of Nutrition·O E Rooyackers, K S Nair
May 19, 2000·The Proceedings of the Nutrition Society·J Henriksson
Sep 19, 2000·Thorax·S J Vane
Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·M SjöstrandP Lönnroth
Feb 15, 2001·Molecular Cell Biology Research Communications : MCBRC·K BaarK Esser
Sep 18, 2001·JAMA : the Journal of the American Medical Association·E VolpiR R Wolfe
Dec 18, 2001·Journal of Applied Physiology·K HamrinJ Henriksson
Jan 16, 2002·JAMA : the Journal of the American Medical Association·Kevin E YarasheskiK Sreekumaran Nair
Jan 25, 2002·Exercise and Sport Sciences Reviews·Mahjabeen HameedGeoffrey Goldspink
Feb 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·T A TrappeW J Evans
Jun 29, 2002·Cellular and Molecular Life Sciences : CMLS·L Jackson Roberts, J D Morrow
Sep 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·N V ChandrasekharanDaniel L Simmons
Oct 9, 2002·The Journal of Nutrition·Robert R Wolfe
Dec 10, 2002·American Journal of Respiratory and Critical Care Medicine·Jason D Morrow, L Jackson Roberts
Feb 8, 2003·Annual Review of Biophysics and Biomolecular Structure·R Michael Garavito, Anne M Mulichak
Apr 16, 2003·The Journal of Cell Biology·Valerie Horsley, Grace K Pavlath
Jul 29, 2003·Exercise and Sport Sciences Reviews·Douglas R BolsterLeonard S Jefferson
Oct 2, 2003·Prostaglandins & Other Lipid Mediators·K J Sales, H N Jabbour
Dec 20, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Rachel J A HelliwellMurray D Mitchell
Feb 24, 2004·Annual Review of Physiology·Michael J RennieFrank W Booth
Mar 30, 2004·Trends in Endocrinology and Metabolism : TEM·Melinda Sheffield-Moore, Randall J Urban

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Citations

Nov 26, 2009·American Journal of Physiology. Endocrinology and Metabolism·Nicholas A BurdTodd A Trappe
Dec 17, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Todd A TrappeChris J Hollon
Aug 7, 2010·Medicine and Science in Sports and Exercise·Susanne Germann PetersenLars Holm
May 10, 2008·Scandinavian Journal of Medicine & Science in Sports·M WernbomT Raastad
May 3, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Chad C CarrollRayna J Gonzales
Mar 30, 2013·Journal of Applied Physiology·Todd A Trappe, Sophia Z Liu
May 16, 2015·Journal of Applied Physiology·Jonathan M PeakeVernon G Coffey

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