Effects of age, experience and inter-alpha inhibitor proteins on working memory and neuronal plasticity after neonatal hypoxia-ischemia

Behavioural Brain Research
Cynthia M GaudetSteven W Threlkeld

Abstract

Neonatal cerebral hypoxia-ischemia (HI) commonly results in cognitive and sensory impairments. Early behavioral experience has been suggested to improve cognitive and sensory outcomes in children and animal models with perinatal neuropathology. In parallel, we previously showed that treatment with immunomodulator Inter-alpha Inhibitor Proteins (IAIPs) improves cellular and behavioral outcomes in neonatal HI injured rats. The purpose of the current study was to evaluate the influences of early experience and typical maturation in combination with IAIPs treatment on spatial working and reference memory after neonatal HI injury. A second aim was to determine the effects of these variables on hippocampal CA1 neuronal morphology. Subjects were divided into two groups that differed with respect to the time when exposed to eight arm radial water maze testing: Group one was tested as juveniles (early experience, Postnatal day (P) 36-61) and adults (P88-113), and Group two was tested in adulthood only (P88-113; without early experience). Three treatment conditions were included in each experience group (HI+Vehicle, HI+IAIPs, and Sham subjects). Incorrect arm entries (errors) were compared between treatment and experience groups across t...Continue Reading

References

Feb 1, 1973·Journal of Comparative and Physiological Psychology·A GlobusM C Diamond
Feb 1, 1981·Annals of Neurology·J E RiceJ B Brierley
Apr 8, 1998·Journal of Neuroscience Methods·R Gibb, B Kolb
Apr 2, 1999·Psychoneuroendocrinology·H A Bimonte, V H Denenberg
Feb 25, 2000·Brain : a Journal of Neurology·D G GadianF Vargha-Khadem
Feb 25, 2000·The International Journal of Biochemistry & Cell Biology·E Fries, A M Blom
Mar 14, 2000·Physiology & Behavior·H A Bimonte, V H Denenberg
Mar 10, 2001·Mental Retardation and Developmental Disabilities Research Reviews·J J Volpe
Jun 22, 2002·Brain : a Journal of Neurology·W John CurtisCharles A Nelson
Oct 18, 2002·Neuropsychology·Jacobus Donders, Nicole M Hoffman
Nov 28, 2002·Mental Retardation and Developmental Disabilities Research Reviews·Glen P Aylward
Dec 21, 2002·Behavioural Brain Research·Timothy E HohDonald P Cain
Feb 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Elise TempleJohn D E Gabrieli
Mar 11, 2003·Dyslexia : the Journal of the British Dyslexia Association·Michael J HautusIan J Kirk
Mar 15, 2003·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Kimberly Andrews EspyArlena Hamby
Mar 20, 2003·Brain Research. Developmental Brain Research·Ciaran J FahertyRichard Jay Smeyne
Feb 6, 2004·Brain Research. Developmental Brain Research·Ann M PeifferR Holly Fitch
Aug 24, 2004·Nature Reviews. Neuroscience·Paula Tallal
Nov 5, 2004·The New England Journal of Medicine·Donna M Ferriero
Sep 10, 2005·Brain : a Journal of Neurology·Lianne J WoodwardTerrie E Inder
Oct 14, 2005·The New England Journal of Medicine·Seetha ShankaranUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
Dec 14, 2005·Journal of Developmental and Behavioral Pediatrics : JDBP·Glen P Aylward
Jun 13, 2006·Behavioural Brain Research·Melissa M McClureR Holly Fitch
Aug 26, 2006·Neurobiology of Learning and Memory·Lenir Orlandi PereiraCarlos Alexandre Netto
Oct 26, 2006·Clinical Therapeutics·Jeffrey M Perlman
Dec 15, 2007·Journal of the International Neuropsychological Society : JINS·Jamie O EdginLianne J Woodward
Mar 7, 2008·Behavioural Brain Research·Panchanan MaitiShashi B Singh
Mar 20, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Benjamin Y Huang, Mauricio Castillo
Sep 19, 2008·Brain : a Journal of Neurology·Miriam H BeauchampPeter J Anderson
Jan 16, 2010·Neurobiology of Learning and Memory·B Blair BradenHeather A Bimonte-Nelson
May 4, 2010·Behavioural Brain Research·Wendy L ComeauBryan E Kolb

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Citations

Mar 12, 2016·Neuroscience·Xiaodi ChenBarbara S Stonestreet
Sep 13, 2016·Developmental Neurobiology·Mariya S SpasovaBarbara S Stonestreet
Jul 6, 2019·Journal of Neuropathology and Experimental Neurology·Adriel Barrios-AndersonBarbara S Stonestreet
Dec 5, 2019·Journal of Neuroscience Research·Boram KimBarbara S Stonestreet
Oct 29, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Clémence DisdierBarbara S Stonestreet
Jul 9, 2020·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Megan S LordJohn M Whitelock
Jun 27, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Aric F LogsdonWilliam A Banks
Feb 10, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kazuki HatayamaBarbara S Stonestreet
Dec 6, 2020·International Journal of Molecular Sciences·Liam M KoehnBarbara S Stonestreet

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