Effects of age on Ca2+ currents in small mesenteric artery myocytes from Wistar-Kyoto and spontaneously hypertensive rats

Hypertension
I M Lozinskaya, R H Cox

Abstract

The purpose of this study was to test the hypothesis that differences in voltage-gated Ca2+ channels increase with age during the development of sustained hypertension in the spontaneously hypertensive rat (SHR). Using patch-clamp methods, we measured whole-cell Ca2+ currents in freshly isolated myocytes from small mesenteric arteries of juvenile (5 to 7 weeks), young (10 to 12 weeks), and mature (19 to 23 weeks) Wistar-Kyoto rats (WKY) and SHR. Indirect tail artery systolic pressure increased progressively with age in SHR (from 125 +/- 5 to 159 +/- 5 to 192 +/- 5 mm Hg) but only in the younger WKY (from 107 +/- 6 to 130 +/- 4 to 136 +/- 4 mm Hg). Peak Ca2+ current density (current per cell capacitance) was larger in SHR than WKY myocytes at all ages (at 6 weeks, 3.5 +/- 0.4 versus 2.3 +/- 0.2 pA/pF; at 12 weeks, 3.8 +/- 0.2 versus 3.1 +/- 0.2; at 20 weeks. 4.9 +/- 0.4 versus 3.3 +/- 0.4). Cell capacitance (surface area) was significantly smaller in 12-week-old SHR than WKY (25.2 +/- 1.1 versus 31.8 +/- 1.6 pF), but no differences were found in the 6- or 20-week-old groups. There were significant differences in Ca2+ current with strain, age, and voltage but no significant age-strain interactions. The ratio of peak Ca2+ current ...Continue Reading

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Citations

Feb 5, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Biny K JosephSung W Rhee
Apr 22, 2008·Journal of Theoretical Biology·Adam KapelaNikolaos M Tsoukias
Jan 24, 2006·Vascular Pharmacology·Swapnil SonkusareNancy J Rusch
Mar 31, 2015·American Journal of Hypertension·Robert H Cox, Samantha Fromme
Apr 24, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yu ChenLijun Shi
Feb 5, 2008·American Journal of Hypertension·Robert H Cox, Irina M Lozinskaya
Aug 9, 2013·American Journal of Physiology. Cell Physiology·Robert H Cox, Samantha J Fromme
May 11, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Luke J Janssen
Jun 24, 2003·Journal of Applied Physiology·Greg G Geary, John N Buchholz

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