Effects of age on responses to isometric exercise. Isometric handgrip in noninvasive screening for cardiovascular disease.

American Heart Journal
M KinoD H Spodick

Abstract

Isometric handgrip (IHG) imposes an acutely increased afterload on the left ventricle. Utilizing systolic time intervals, we studied various responses to IHG, measured as changes from resting values with near-maximum IHG, in old normal (ON) subjects, young normal (YN) subjects, and old patients with hypertensive heart disease (HHD) and patients with coronary artery disease (CAD). There were no differences in responses to IHG between ON and patients with HHD or patients with CAD. However, there were clear differences between the responses of ON and YN subjects. Increase in heart rate (HR) was much more prominent in YN (ON vs. YN = +11.6 +/- 2.6 vs. +15.6 +/- 5.7 beats per minute p less than 0.001). Pre-ejection period (PEP) end isovolumic contraction time (IVCT) increased in ON but decreased in YN (PEP + 6.2 +/- 1.7 vs. -11.0 +/- 3.7 msec., p less than 0.001; IVCT +8.1 +/- 2.2 vs. -13.8 +/- 3.4 msec., p less than 0.001. Shortening of LVET was much more marked in YN (-6.5 +/- 4.1 VS. -63.3 +/- 9.9 msec. p less than 0.001), but this was entirely due to the HR differences since there was no difference in ejection time index (+ 5.1 +/- 3.4 vs. -0.4 +/- 7.3 msec. p greater than 0.5). IHG produced no significant differences between ON...Continue Reading

References

May 6, 1974·The American Journal of Cardiology·S ZoneraichJ Rodenrys
Jul 1, 1973·British Heart Journal·W GrossmanL Dexter
Jul 1, 1973·Circulation·D H Spodick, V M Quarry-Pigott
Jan 1, 1974·The American Journal of Cardiology·P LudbrookR A O'Rourke
May 20, 1974·The American Journal of Cardiology·J C HaisslyH Denolin
Apr 1, 1971·The American Journal of Cardiology·R C TalleyJ L McNay
Jan 1, 1957·Geriatrics·N W SHOCK
May 1, 1958·Circulation Research·E BRAUNWALDW N STAINSBY
Jun 1, 1963·Circulation Research·A G WALLACES J SARNOFF
Oct 1, 1948·Journal of Gerontology·T H HOWELL

❮ Previous
Next ❯

Citations

Jul 29, 2011·European Journal of Applied Physiology·K KrzemińskiK Nazar
Jul 12, 2001·Psychophysiology·P J GianarosR M Stern
Mar 1, 1983·The American Journal of Cardiology·R H Chaney, S Arndt
Apr 1, 1979·Circulation·W P LairdF D Huffines
Jan 1, 1992·Postgraduate Medicine·J D Bonema, M E Maddens

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.