Effects of ageing and experimental diabetes on insulin-degrading enzyme expression in male rat tissues

Biogerontology
Ekaterina G KochkinaNatalia N Nalivaeva

Abstract

Due to an increasing life expectancy in developing countries, cases of type 2 diabetes and Alzheimer's disease (AD) in the elderly are growing exponentially. Despite a causative link between diabetes and AD, general molecular mechanisms underlying pathogenesis of these disorders are still far from being understood. One of the factors leading to cell death and cognitive impairment characteristic of AD is accumulation in the brain of toxic aggregates of amyloid-β peptide (Aβ). In the normally functioning brain Aβ catabolism is regulated by a cohort of proteolytic enzymes including insulin-degrading enzyme (IDE) and their deficit with ageing can result in Aβ accumulation and increased risk of AD. The aim of this study was a comparative analysis of IDE expression in the brain structures involved in AD, as well as in peripheral organs (the liver and kidney) of rats, during natural ageing and after experimentally-induced diabetes. It was found that ageing is accompanied by a significant decrease of IDE mRNA and protein content in the liver (by 32 and 81%) and brain structures (in the cortex by 58 and 47% and in the striatum by 53 and 68%, respectively). In diabetic animals, IDE protein level was increased in the liver (by 36%) and in...Continue Reading

References

Apr 10, 1992·Science·J A Hardy, G A Higgins
Dec 5, 1991·European Journal of Biochemistry·D MüllerD Richter
Mar 26, 1998·Biochemical and Biophysical Research Communications·W C DuckworthF G Hamel
Jun 13, 2000·Advances in Experimental Medicine and Biology·N M HooperA J Turner
Jan 26, 2002·The Journal of Biological Chemistry·Dieter EdbauerChristian Haass
Aug 28, 2002·Biochemical Society Transactions·D M WalshD J Selkoe
Feb 19, 2003·Journal of Alzheimer's Disease : JAD·E HoneR N Martins
Mar 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wesley FarrisSuzanne Guenette
Aug 6, 2003·Trends in Neurosciences·Laura Gasparini, Huaxi Xu
Aug 24, 2004·The Journal of Biological Chemistry·Jorge GhisoBlas Frangione
Feb 1, 2005·Annals of the New York Academy of Sciences·Natalia N NalivaevaaAnthony J Turner
Oct 20, 2005·Neuroscience Letters·Troy L CarterSam Gandy
Aug 1, 2006·Neurobiology of Aging·Behnosh F BjörkCaroline Graff
May 13, 2008·Cellular and Molecular Life Sciences : CMLS·E MalitoW-J Tang
Dec 17, 2008·Journal of Molecular Biology·Chiara CiaccioMassimo Coletta
Nov 21, 2009·Current Pharmaceutical Design·A Fernández-GambaE M Castaño
Jan 29, 2010·The New England Journal of Medicine·Henry W Querfurth, Frank M LaFerla
Apr 24, 2010·Journal of Endocrinological Investigation·Y LiuG Wang
Sep 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yan KongYingying Le
Sep 21, 2011·Journal of Molecular Neuroscience : MN·Natalia N NalivaevaAnthony J Turner
Oct 26, 2011·Cellular Signalling·Caroline BeckettAnthony J Turner
Nov 30, 2011·Journal of Neurochemistry·Natalia N NalivaevaAnthony J Turner
Apr 27, 2012·Rejuvenation Research·Giulia AccardiGiuseppina Candore
Jul 13, 2012·Journal of Alzheimer's Disease : JAD·Claudine L BitelPeter H Frederikse
Aug 18, 2012·International Journal of Alzheimer's Disease·N N NalivaevaA J Turner

❮ Previous
Next ❯

Citations

Sep 18, 2015·Neurochemical Research·Natalia N NalivaevaAnthony J Turner
Mar 12, 2016·Journal of Alzheimer's Disease : JAD·Melissa A Schilling
Feb 3, 2019·British Journal of Pharmacology·Natalia N Nalivaeva, Anthony J Turner
Jun 22, 2017·Critical Reviews in Biochemistry and Molecular Biology·Grazia R TundoMassimo Coletta
Dec 11, 2019·Drug Development Research·Kavya JashKiran Kalia
Mar 30, 2018·Cellular and Molecular Life Sciences : CMLS·Diego SbardellaMassimo Coletta
Aug 4, 2018·Frontiers in Endocrinology·Carola RotermundJulia C Fitzgerald
Aug 5, 2018·Scientific Reports·Zuzana NovosadováAlena Sumová
Jun 1, 2021·Frontiers in Endocrinology·Carine MarmentiniMirian A Kurauti
Jul 6, 2021·Frontiers in Neuroscience·Danhua DingJun Wu
Aug 28, 2018·Journal of Medicinal Chemistry·Dan YangZigang Li
Aug 17, 2021·The Journal of Pathology·Luís SousaHugo Vicente Miranda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Aging & Diabetes

This feed focuses on the role of the aging process on developing diabetes.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.