Effects of aging and acid reflux on esophageal motility

Digestion
Noriyuki KawamiChoitsu Sakamoto

Abstract

It is generally thought that esophageal motility decreases with age; however, a decrease in esophageal motility may also be caused by esophagitis. The aim of this study is to investigate the effects of aging and acid reflux on esophageal motility. 40 young (under 45) healthy subjects (HS), 40 elderly (over 65) HS, and 40 elderly (over 65) patients with mild reflux esophagitis (RE), underwent esophageal high-resolution manometry (HRM). Lower esophageal sphincter pressure (LESP), primary peristalsis (PP), and secondary peristalsis (SP) were evaluated. There was no difference in the LESP and also in the success rate of PP between young and elderly HS or between elderly HS and RE. There was no difference in the distal contractile integral (DCI) of PP and SP between the young and elderly HS, but in the elderly RE, it was significantly lower than in the elderly HS. There was no difference in the success rate of SP between elderly HS and RE, but in elderly HS it was significantly lower than in young HS. Aging may cause a decrease in the success rate of SP, and acid reflux itself may cause a decrease of the DCI in PP and SP.

Citations

Jun 28, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C CockT I Omari
Feb 7, 2017·Journal of Neurogastroenterology and Motility·Young Kwang ShimDong Ho Lee
Nov 5, 2019·Esophagus : Official Journal of the Japan Esophageal Society·Nana TakenouchiKatsuhiko Iwakiri
Jul 26, 2018·Journal of Medical Ultrasonics·Hiroki SuharaHidemi Goto
Nov 1, 2020·Annals of the New York Academy of Sciences·C Prakash GyawaliJerzy Sarosiek

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